Clinical Trials

We have both prevention and symptomatic trials. Our current prevention trial is listed at the top, followed by our symptomatic trials.

Are you having memory problems or trouble thinking clearly? Have you been diagnosed with Mild Cognitive Impairment (MCI) or mild dementia due to Alzheimer’s disease (early AD)? Are you interested in participating in a clinical trial to help better understand how to slow the progression of Alzheimer’s disease and to evaluate an investigational treatment for individuals with early AD?

This research study (also known as a clinical trial) is of an investigational drug called gantenerumab. If you have Alzheimer’s disease (AD) or may have early symptoms of AD, you may be eligible for this study. AD is a slow progressive disease of the brain that affects memory and other normal brain functions. The brains of individuals with AD have an abundance of plaques and tangles. Plaques are deposits of a protein called amyloid; tangles are twisted fibers of another protein called tau.

Have you been diagnosed wit bipolar disorder? Are you currently depressed? Are you over 50 years old? We are investigating the effects of Low Field Magnetic Stimulation (LFMS) on Bipolar Depression in Older Adults. Participating in this study involves clinical screening, two 2-hour sessions which include fMRI imaging and LFMS, and two follow up phone calls.

Participants may be compensated up to $200.

Contact Hannah Heintz at 617.855.3225 or hheintz@partners.org for information.

Are you caring for a family member who has Alzheimer’s disease? Does your family member have symptoms of aggression or agitation or resist care?

You and your family member may be eligible for a research study evaluating low dose lithium treatment at McLean Hospital in Belmont, MA. Patients with Alzheimer’s disease are eligible. Participants will meet with a geriatric psychiatrist every two weeks for the duration of the twelve-week study.

Contact Hannah Heintz at 617.855.3225 or hheintz@partners.org for more information.

We are seeking individuals that have been diagnosed with probable Alzheimer’s Disorder, Frontotemporal Dementia, or Dementia with Lewy Bodies with or without anxiety, agitation, or have irritability symptoms. The purpose of this study is to measure participants autonomic nervous physiology and actigraphy of agitation, irritability and anxiety in Alzheimer’s Disease and Alzheimer’s Disease Related Dementias.

The Music, Imaging, and Neural Dynamics (MIND) Laboratory is seeking older adults with Mild Cognitive Impairment (MCI) to participate in a research study on how music intervention affects the brain and gene expression. All studies will take place at the Northeastern Interdisciplinary Science and Engineering Complex. Participants must be above 50 years old, have normal hearing, and pass pre-screening to take part in the study. Eligible participants will complete surveys, listening and cognitive tasks, MRI scanning of their brain, and blood draws.

Our study uses repetitive non-invasive transcranial magnetic stimulation to target areas of the brain that control memory and language in patients with amnestic Mild Cognitive Impairment or Primary Progressive Aphasia to improve their memory or language performance.

This study is focused on determining the effects of methylphenidate (also known as Ritalin) on the cognition, behavioral symptoms, and daily activities of people with Alzheimer’s Disease (AD) and other dementias using traditional office-based assessments as well as daily brain training games and Fitbit activity tracking.

Have you been diagnosed with early or mild Alzheimer’s disease, and between the ages of 50 to 100? Would you like to try non-invasive therapy?