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Lori B. Chibnik
Longitudinal modeling, genetics & genomics, multi-ancestral cohorts, predictive modeling, science and statistics education
Lori Chibnik, PhD, MPH is a biostatistician and Assistant Professor with an appointment in the Department of Neurology at Massachusetts General Hospital and the Department of Epidemiology at the Harvard T.H. Chan School of Public Health. She received her MPH in International Health and her PhD in biostatistics from Boston University where she worked on predictive modeling methods for disease risk. Over her career, she has developed and assessed predictive models for diseases such as autoimmune diseases, HIV and pre-natal screening and continues to apply her methods to complex diseases. Her current research focuses primarily on genetics and genomics of Alzheimer’s Disease and dementia with an emphasis on longitudinal cohorts and cognition. She serves as the co-lead of the Data and Statistics Core of the Massachusetts Alzheimer’s Disease Research Center (MADRC) and Director of the Biostatistical Consulting Service in the Department of Neurology. In addition to her research, she is internationally renowned for her training programs and innovative teaching techniques, having developed multiple courses in biostatistics for varied audiences, most recently a series specific to the needs of scientists in sub-Saharan Africa. Currently she directs the Global Initiative for Neuropsychiatric Genetics Education and Research (GINGER) program at the Harvard-Chan School and the Broad Institute of MIT and Harvard.
Chibnik LB, Shulman JM, Leurgans SE, Schneider JA, Wilson RS, Tran D, et.al. CR1 is associated with amyloid plaque burden and age-related cognitive decline. Annals of neurology. 2011;69(3):560-9. Epub 2011/03/11. PMCID: PMC3066288.
Chibnik LB, Yu L, Eaton M, Srivastava GP, Schneider JA, Kellis M, et.al. Alzheimer's loci: epigenetic association and interaction with genetic factors. Annals Clin Trans Neuro.2015;2(6):636-47. Epub 2015/07/01. doi: 10.1002/acn3.201. PubMed PMID: 26125039; PMCID: PMC4479524.
Chibnik LB, White CC, Mukherjee S, Raj T, Yu L, Larson EB, et al. Susceptibility to neurofibrllary tangles: role of the PTPRD locus and limited pleitropy with other neuropathologies. Molecular Psychiatry, 2018;23(6):1521-9. Epub 2017/03/23. doi: 10.1038/mp.2017.20. PubMed PMID: 28322283; PMCID: PMC5608624.
Chibnik, LB, Wolters FJ, Backman K, Beiser A, Berr C, Bis JC. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium. Eur J Epidemiol. 2017;32(10):931-8. Epub 2017/10/25. doi: 10.1007/s10654-017-0320-5. PubMed PMID: 29063414; PMCID: PMC5680377.
Yu L, Chibnik, LB, Srivastava GP, Pochet N, Yang J, Xu J, Kozubek J, Obholzer N, Leurgans SE, Schneider JA, Meissner A, De Jager PL, Bennett DA. Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. JAMA Neurol. 2015;72(1):15-24. Epub 2014/11/05. doi: 10.1001/jamaneurol.2014.3049. PubMed PMID: 25365775; PMCID: PMC4344367.
Mostafavi S, Gaiteri C, Sullivan SE, White CC, Tasaki S, Xu J, Taga M, Klein HU, Patrick E, Komashko V, McCabe C, Smith R, Bradshaw EM, Root DE, Regev A, Yu L, Chibnik, LB, Schneider JA, Young-Pearse TL, Bennett DA, De Jager PL. A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease. Nat Neurosci. 2018;21(6):811-9. Epub 2018/05/29. doi: 10.1038/s41593-018-0154-9. PubMed PMID: 29802388; PMCID: PMC6599633.
Goodman MO, Chibnik, L, Cai T. Variance components genetic association test for zero-inflated count outcomes. Genet Epidemiol. 2019;43(1):82-101. Epub 2018/10/26. doi: 10.1002/gepi.22162. PubMed PMID: 30353568; PMCID: PMC6534267.
De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, Tang A, Raj T, Replogle J, Brodeur W, Gabriel S, Chai HS, Younkin C, Younkin SG, Zou F, Szyf M, Epstein CB, Schneider JA, Bernstein BE, Meissner A, Ertekin-Taner N, Chibnik, LB, Kellis M, Mill J, Bennett DA. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci. 2014;17(9):1156-63. Epub 2014/08/19. doi: 10.1038/nn.3786. PubMed PMID: 25129075; PMCID: PMC4292795.
More publications may be found at www.ncbi.nlm.nih.gov/