August 10, 2020
Journal of Neuroinflammation (July 31, 2020) Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration
Neuronal damage in acute CNS injuries and chronic neurodegenerative diseases is invariably accompanied by an astrocyte reaction in both mice and humans. However, whether and how the nature of the CNS insult—acute versus chronic—influences the astrocyte response, and whether astrocyte transcriptomic changes in these mouse models faithfully recapitulate the astrocyte reaction in human diseases remains to be elucidated.
July 14, 2020
Boston Business Journal (July 14, 2020) Covid-19 threatens ‘precious’ Alzheimer’s research resource: seniors
Joining a clinical trial may not be the first idea that pops into your head when wondering how to make new friends after moving to a new area. But for Alice Bailey, it was the “most incredible gift.”
Read the full article here.
July 8, 2020
Journal of Prevention of Alzheimer's Disease (July 5, 2020) The Computerized Cognitive Composite (C3) in A4, an Alzheimer’s Disease Secondary Prevention Trial
Computerized cognitive testing may be as valid as paper and pencil testing in detecting subtle amyloid-related decrements. Remote and computerized cognitive testing promises to increase the speed and ease of research progress.
July 7, 2020
Nature Medicine (June 22, 2020) Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Why do some people with AD slide rapidly into severe dementia, while others decline gradually over more than a decade? Part of the answer could come down to which biochemical forms of tau inhabit a person’s brain, suggests a study published June 22 in Nature Medicine.
July 1, 2020
Guest Column by Alice Bailey, research participant at Brigham and Women’s Hospital, Center for Alzheimer Research and Treatment (CART): https://cambridge.wickedlocal.com/news/20200630/guest-column-alzheimers-research-needs-your-help
June 24, 2020
Dr. Seth Gale of Brigham & Women's Center for Alzheimer Research and Treatment discusses the status of research studies during COVID-19. The interview also features clinical trial research participant Alice Bailey.
June 23, 2020
Neuron (June 8, 2020) Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology
“In this multi-institution collaboration study, Dr. Yang and colleagues analyzed over 750 autopsied human brain samples and discovered and replicated that genetic variants in the TMEM106B and RBFOX1 genes change thousands of brain genes’ expression.
May 10, 2020
I lost my mother at about this time last year, after her 10-year struggle with Alzheimer's disease. During this past year, kind friends have checked in at holidays and birthdays, understandably assuming these first landmark occasions without my mom would be difficult. The truth is something that I was at first ashamed to admit, let alone articulate: Grieving her nonw, when the loss is complete, feels nothing like I had expected. It feels easy.
April 11, 2020
MGH News (April 11, 2020): Mass General Team Detects Alzheimer’s Early Using Electronic Health Records
A team of scientists from Massachusetts General Hospital (MGH) has developed a software-based method of scanning electronic health records (EHRs) to estimate the risk that a healthy person will receive a dementia diagnosis in the future
April 9, 2020
The first published data from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial support the hypothesis that higher brain amyloid levels represent an early preclinical stage of Alzheimer's disease (AD).