August 1, 2018
Building on their development of the first culture system to replicate fully the pathology behind Alzheimer’s disease, a Massachusetts General Hospital (MGH) research team has now produced a system that includes neuroinflammation, the key biological response that leads to the death of brain cells. The investigators describe their system, which incorporates the glial cells that that not only surround and support neurons but also provide some immune system functions, in a paper published in Nature Neuroscience.
July 30, 2018
CNN News (July 30, 2018): Borrowing from the Cancer Playbook to Find Treatment for Alzheimer's Disease
It's been notoriously difficult to develop medicines for Alzheimer's disease, the sixth leading cause of death in the United States. Each year, it seems, pharmaceutical companies release data from studies of promising drug candidates that merit only a collective sigh of disappointment.
In search of fresh ideas, researchers have begun to borrow a phrase or two from the more familiar language of cancer treatment.
July 26, 2018
An exciting update on the race to end Alzheimer's disease: in a clinical trial, a new drug reduced amyloid plaques and improved cognitive function -- the first time a drug has had both effects. Dr. Reisa Sperling of the MADRC, quoted in the The New York Times, said, "I don't know if we've hit a home run yet. It's important not to over-conclude on the data. But as a proof of concept, I feel like this is very encouraging." To read the article in its entirety, click here.
July 26, 2018
Alzheimer's Association (July 25, 2018): Study Shows Intensive Blood Pressure Control Reduces Risk of Mild Cognitive Impairment (MCI) & the Combined Risk of MCI and Dementia
Significant reductions in the risk of mild cognitive impairment (MCI)*, and the combination of MCI and dementia**, have been shown for the first time through aggressive lowering of systolic blood pressure in new research results from the federally-funded SPRINT MIND Study reported at the Alzheimer’s Association International Conference (AAIC) 2018 in Chicago.
July 24, 2018
PR NewsWire (July 23, 2018): New National Strategy For Recruitment And Participation In Alzheimer's Disease Clinical Trials Takes Shape
Increased public and private investments in Alzheimer's disease research have brought about a proliferation of potential therapeutic targets. Drugs and other interventions to hit those targets are moving into clinical trials. Other studies are helping us better understand risks for dementia and examining best approaches to clinical and long-term care. Yet engagement and participation has not kept pace with the acceleration of research and great need for volunteers.
July 24, 2018
When asking why more women than men have Alzheimer’s disease or dementia – nearly two-thirds of Americans with the disease are women – the prevailing explanation has been that women live longer and that it is a disease associated with aging.
July 23, 2018
CNBC (July 22, 2018): Top Alzheimer’s Researchers Hope that Near-100 Dementia Drugs in Trials are Moving Closer to a Breakthrough
The search for an Alzheimer’s disease cure has been dogged by pharmaceutical failures, but a network of the world’s top dementia scientists released a report on Sunday saying that the number of drugs making it to phase two and phase three of clinical trials encourages them to believe that a blockbuster may be among compounds in the current development pipeline.
July 23, 2018
Nine wary residents gathered around a table in the basement of Boston’s Kenmore Abbey Apartments to broach a subject most people tend to avoid: death.
The residents - all Chinese-born men and women between 64 and 85 years old — sipped hot green tea. They listened poker-faced as a facilitator, Shiyun “Cici” Guan of the nonprofit Boston Senior Home Care, spoke in Cantonese about the need to designate a family member as a proxy to make health care decisions for them in the event of emergency or serious illness.
July 18, 2018
Boston Globe (July 18, 2018): As Older Population Grows, Massachusetts Angles to Become the Silicon Valley for ‘Age-Tech’
Pillo, a startup in Boston’s Fort Point district, has developed a robot that sits on your grandparents’ kitchen counter, greets them in the morning, and gently reminds them to take their pills.
Another early-stage local company called Eversound sells wireless headphones whose volume controls let seniors with varying levels of hearing loss exercise or watch movies together.
July 16, 2018
Diagnosed with Alzheimer’s in 2015, 75-year-old Brenda Whittle still enjoys jigsaws, sewing and dancing. New activities are less appealing, but participating in Alzheimer’s research and drug trials is an exception. She’s so at ease with loud brain scans, she even falls asleep during them.