Our team is investigating the differences between healthy older individuals and those with Cerebral Amyloid Angiopathy (CAA), a form of stroke-related dementia. We hope to identify biological markers through MRIs, memory/attention testing, and optional spinal fluid samples to learn about the progression of both CAA and memory loss.
We are doing this research to investigate how the ability to accurately assess one’s own memory performance changes in normal aging and brain disease, such as mild cognitive impairment or Alzheimer’s disease. Each participant will complete different tests that focus on memory self-awareness. These tests will also be compared to imaging (scans) of the participant’s brain.
The Trial Ready Cohort (TRC) study is to build a large group, or “cohort”, of individuals who are interested in being recruited into clinical trials aimed at reducing the risk of developing AD dementia. To do this, we will collect data (via blood draws and various brain images such as a MRI) from cognitively normal or minimally impaired individuals and then inform them if a trial may be appropriate for them.
We are interested in understanding how EEG signals, particularly during sleep, relate to neurodegenerative diseases such as Alzheimer's disease.