AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.

Contact: (617) 278-0600.                                                                                                            Additional information: https://www.aheadstudy.org                                                                  Location:  60 Fenwood Road, Boston, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

Contact: MemoryAndAging@mgh.harvard.edu

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org

Locust Study – Tracking the Origin of Tau Pathology: This study will help researchers distinguish healthy brain aging compared to brain changes in individuals with brain diseases such as Alzheimer’s disease (AD). This observational study is for cognitively healthy participants ages 36-56. Individuals will be asked to complete cognitive testing, MRI scans, blood draws and PET scans to help researchers understand the structure and function of the locus coeruleus, one of the first sites to harbor tau pathology in the brain. This study has 8 visits over 3 years.

Contact : Nina Engels, NENGELS@mgh.harvard.edu

Additional information: Locust Study

Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently used by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/actru_bcg_pilot.
Location: 149 13^th Street, Charlestown, MA

Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu

Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13^th Street, Charlestown, MA

Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13^th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study–   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.
Contact: Sam Huang shuang27@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13^th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu

Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
Contact: Jairo Martinez  jmartinez24@mgh.harvard.edu
Additional Information: BLAST Flyer Spanish
Location: 149 13^th Street, Charlestown, MA

Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
Additional information: https://rally.partners.org/study/_latino_habs
Location: 149 13^th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu

Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.
Contact: Colleen Fitzpatrick, cdfitzpatrick@bwh.harvard.edu
Additional information: https://rally.partners.org/study/study_scd.              Location: 149 13^th Street, Charlestown, MA

Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Nick Stevenson, nestevenson@mgh.harvard.edu                                          Additional information: https://rally.partners.org/study/sonnet                          Location:149 13^th Street, Charlestown, MA

Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank 
Location: 149 13^th Street, Charlestown, MA

Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently aused by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/actru_bcg_pilot
Location: 149 13^th Street, Charlestown, MA

Bacillus Calmette-Guerin (BCG) vaccine study – A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently used by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/actru_bcg_pilot
Location: 149 13^th Street, Charlestown, MA

Niagen Study -A pilot study for the use of nicotinamide riboside (an alternative form of B3) which works in the body to help convert food to energy and repair damaged DNA. This study will evaluate its effect on cognitive and behavioral symptoms.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/pactad_niagen
Location: 149 13^th Street, Charlestown, MA

Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu

Additional information: https://rally.partners.org/study/study_iadl
Location:149 13^th Street, Charlestown, MA

Sleep on Neural Networks in Brain Aging (SONNET) – A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13^th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
Additional information multimodal brochure
Location: 149 13^th Street, Charlestown, MA

Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact:  KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13^th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study–   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
Contact: Sam Huang shuang27@mgh.harvard.edu
Additional information: https://rally.partners.org/study/risk_of_alzheimers
Location: 149 13^th Street, Charlestown, MA

Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
Contact: pbm@mgh.harvard.edu
Additional Information:
https://rally.partners.org/study/trapad_study

Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu

Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu
Additional Information: https://rally.partners.org/study/novartis
Location: 149 13th Street, Charlestown, MA

Athira – a phase II study of ATH -1017, an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.partners.org/study/ath_1017
Location: 149 13th Street, Charlestown, MA                                                                   

Memory Awareness –A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
Contact: Sharon Wang, swang72@mgh.harvard.edu

More information: https://rally.partners.org/study/the_memoryawareness_study
Location: 149 13^th Street, Charlestown, MA

Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
Additional information:  https://rally.partners.org/study/sonnet
Location: 149 13th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
Additional information Multimodal brochure
Location: 149 13^th Street, Charlestown, MA

Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: Katherine Cropp,  KCROPP1@mgh.harvard.edu 617-643-4802
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13^th Street, Charlestown, MA

Tau PET Imaging Study A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

Longitudinal Early Onset Disease Study (LEADS)– A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
Additional information: LEADS flyer
Location: 149 13^th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study–   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
Contact: Sam Huang shuang27@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13^th Street, Charlestown, MA

Resilient Together Study– A study seeking to understand the experiences, needs, and preferences of individuals with a form of young onset dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
Contact: Paula Popok 617-724-0051 ppopok@mgh.harvard.edu
Additional information: https://rally.partners.org/study/resilienttogether
Location: 149 13^th Street, Charlestown, MA

Dementia, Care Planning and Surgery -This is a study to help understand the effectiveness of advance care planning for participants with dementia and either considering or considered surgery.
Contact: Stephen Perez: 617-732-6176 sperez14@bwh.harvard.edu
Additional information: https://rally.partners.org/study/careplanningdementia
Location:  60 Fenwood Road, Boston, MA

Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.partners.org/study/johnsonandjohnson

Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu

Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.partners.org/study/novartis
Location: 149 13th Street, Charlestown, MA

Ornish – A research study designed to see if lifestyle changes may slow down, lessen, or potentially reverse the progression of Alzheimer’s disease. Participants in this study will make changes to their diet, and participate in daily exercise, stress management, and group support.
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information:  https://rally.partners.org/study/lifestyleintervention  
Location: 149 13th Street, Charlestown, MA    

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      Contact: Erin Krahn, ekrahn@mgh.harvard.edu

• Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
  Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu

     Location: 149 13^th Street, Charlestown, MA 

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, a family member with medical history of FTD.
  Contact: Erin Krahn, ekrahn@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
  Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
  Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA 
• AARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
  Contact: Erin Krahn, ekrahn@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
  Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

   

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
  Contact: Erin Krahn, ekrahn@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease.
  Contact: Molly Quan mquan4@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

   

• Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
  Contact: Molly Quan mquan4@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease.
  Contact: Molly Quan mquan4@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA
•  
• Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
  Contact: Molly Quan mquan4@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• Vascular Pathology in Early and Asymptomatic Cerebral Angiopathy –This study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
  Contact: Vanessa Gonzlaez vagonzalez@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/caamemorystudy
  Location: Mass General Hospital

• Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
  Contact: Jairo Martinez  jmartinez24@mgh.harvard.edu
  Additional Information: BLAST Flyer Spanish
  Location: 149 13^th Street, Charlestown, MA
•  
• Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
  Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/_latino_habs
  Location: 149 13^th Street, Charlestown, MA

• Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
  Contact: MemoryAndAging@mgh.harvard.edu
  

• MADRC Memory & Aging Study: An observational study for participants 65 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. 

    Contact: jjohanson1@mgh.harvard.edu

• Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
  Contact Erin Krahn: ekrahn@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA
•  
• Resilient Together – A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
  Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu
  Additional information https://rally.partners.org/study/resilienttogether
  Location: 149 13^th Street, Charlestown, MA

Northeastern University Music-Based Intervention Research Study
MBI Flyer 
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com 

McLean Hospital
Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

Beth Israel Deaconess Medical Center
Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

• AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.
  Contact: 617-278-0600
  Additional information: : https://www.aheadstudy.org
  Location:  60 Fenwood Road, Boston, MA

• Niagen Study -A pilot study for the use of nicotinamide riboside (an alternative form of B3) which works in the body to help convert food to energy and repair damaged DNA. This study will evaluate its effect on cognitive and behavioral symptoms.
  Contact:  KCROPP1@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/pactad_niagen
  Location: 149 13^th Street, Charlestown, MA

• Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently used by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
  Contact: KCROPP1@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/actru_bcg_pilot
  Location: 149 13^th Street, Charlestown, MA

• Niagen Study -A pilot study for the use of nicotinamide riboside (an alternative form of B3) which works in the body to help convert food to energy and repair damaged DNA. This study will evaluate its effect on cognitive and behavioral symptoms.Contact: KCROPP1@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/pactad_niagen
  Location: 149 13^th Street, Charlestown, MA

• Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently used by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
  Contact: KCROPP1@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/actru_bcg_pilot
  Location: 149 13^th Street, Charlestown, MA

• Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
  Contact: pbm@mgh.harvard.edu
  Additional Information:
  https://rally.partners.org/study/trapad_study 

• Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
  Contact: Kate Cropp, KCROPP1@mgh.harvard.edu
  Additional Information: https://rally.partners.org/study/novartis
  Location: 149 13th Street, Charlestown, MA

• Athira – a phase II study of ATH -1017 , an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
  Contact: Kate Cropp, KCROPP1@mgh.harvard.edu   617-723-2351
  Additional Information: https://rally.partners.org/study/ath_1017
  Location: 149 13th Street, Charlestown, MA

• Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
  Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-723-2351
  Additional Information: https://rally.partners.org/study/johnsonandjohnson

• Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
  Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-723-2351
  Additional Information:  https://rally.partners.org/study/novartis
  Location: 149 13th Street, Charlestown, MA

• Transcranial Magnetic Stimulation Study -This study evaluates use of repetitive transcranial magnetic stimulation to target areas of memory and language in patients with amnestic mild cognitive impairment and the logogenic or non-fluent variant of primary progressive aphasia.
  Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• Check back soon

Northeastern University Music-Based Intervention Research Study
MBI Flyer 
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com

McLean Hospital
Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

Beth Israel Deaconess Medical Center
Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

• APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
  www.aptwebstudy.org
• Locust Study – Tracking the Origin of Tau Pathology: This study will help researchers distinguish healthy brain aging compared to brain changes in individuals with brain diseases such as Alzheimer’s disease (AD). This observational study is for cognitively healthy participants ages 36-56. Individuals will be asked to complete cognitive testing, MRI scans, blood draws and PET scans to help researchers understand the structure and function of the locus coeruleus, one of the first sites to harbor tau pathology in the brain. This study has 8 visits over 3 years.
• Contact : Nina Engels, NENGELS@mgh.harvard.edu
  Additional information: Locust Study

• Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.
  Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu

     Additional information: https://rally.partners.org/study/study_iadl
     Location: 149 13^th Street, Charlestown, MA 

• Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
  Contact: KCROPP1@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/lifespan_biobank
  Location: 149 13^th Street, Charlestown, MA 

• Alzheimer’s Disease EEG Sleep Study–   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.
  Contact: Sam Huang shuang27@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/noninvasive_biomarkers
  Location: 149 13^th Street, Charlestown, MA 

• Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
  Contact: MemoryAndAging@mgh.harvard.edu.

• Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
• Contact: Jairo Martinez | jmartinez24@mgh.harvard.edu
  
• Additional Information: BLAST Flyer Spanish
• Location: 149 13^th Street, Charlestown, MA 
• Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
• Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/_latino_habs
  Location: 149 13^th Street, Charlestown, MA
• Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
  Contact: MemoryAndAging@mgh.harvard.edu
  

• Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.
  Contact: Colleen Fitzpatrick, cdfitzpatrick@bwh.harvard.edu
  Additional information: https://rally.partners.org/study/study_scd
  Location: 149 13^th Street, Charlestown, MA

   

• Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
  Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/sonnet
  Location:149 13^th Street, Charlestown, MA

• Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
  Contact: KCROPP1@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/lifespan_biobank
  Location: 149 13^th Street, Charlestown, MA

• Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
  Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu                   Additional information: https://rally.partners.org/study/study_iadl Location: 149 13^th Street, Charlestown, MA 

• Sleep on Neural Networks in Brain Aging (SONNET) –A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
  Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/sonnet
  Location:149 13^th Street, Charlestown, MA 

• Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
  Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA 

• Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
  Contact: KCROPP1@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/lifespan_biobank
  Location: 149 13^th Street, Charlestown, MA 

• Alzheimer’s Disease EEG Sleep Study–   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
  Contact: Sam Huang shuang27@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/risk_of_alzheimers
  Location: 149 13^th Street, Charlestown, MA     

• Memory Awareness – A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
  Contact: Sharon Wang, swang72@mgh.harvard.edu                                                Additional info:                  https://rally.partners.org/study/the_memoryawareness_study.                            Location: 149 13^th Street, Charlestown, MA 
• Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
  Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
  Additional information https://rally.partners.org/study/sonnet
  Location: 149 13^th Street, Charlestown, MA 

• Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
  Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
  Additional information: Multimodal flyer
  Location: 149 13^th Street, Charlestown, MA 

• Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
  Contact: KCROPP1@mgh.harvard.edu   (617) 643-4802                                           Additional information: https://rally.partners.org/study/lifespan_biobank.   Location: 149 13^th Street, Charlestown, MA 

• Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
  Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• Longitudinal Early Onset Disease Study (LEADS)– A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
  Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
  Additional information: AA_LEADS-Brochure_
  Location: 149 13^th Street, Charlestown, MA

• Alzheimer’s Disease EEG Sleep Study–   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
  Contact: Sam Huang shuang27@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/noninvasive_biomarkers
  Location: 149 13^th Street, Charlestown, MA 

• Resilient Together Study- A study seeking to understand the experiences, needs, and preferences of individuals with a form of young onset dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
  Contact: Paula Popok 617-724-0051 ppopok@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/resilienttogether
  Location: 149 13^th Street, Charlestown, MA

• Dementia, Care Planning and Surgery -This is a study to help understand the effectiveness of advance care planning for participants with dementia and either considering or considered surgery.
  Contact: Stephen Perez: sperez14@bwh.harvard.edu  (617) 732-6176
  Additional information: https://rally.partners.org/study/careplanningdementia
  Location:  60 Fenwood Road, Boston, MA

• Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
  Contact: MemoryAndAging@mgh.harvard.edu 
• Ornish – A research study designed to see if lifestyle changes may slow down, lessen, or potentially reverse the progression of Alzheimer’s disease. Participants in this study will make changes to their diet, and participate in daily exercise, stress management, and group support.
  Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
  Additional Information:  https://rally.partners.org/study/lifestyleintervention  
  Location: 149 13th Street, Charlestown, MA    

• ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)– A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
  Contact: Erin Krahn, ekrahn@mgh.harvard.edu

• Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
  Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
  Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
  Location: 149 13^th Street, Charlestown, MA

• Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease. Contact: Molly Quan mquan4@mgh.harvard.edu

  Location: 149 13^th Street, Charlestown, MA

• Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
  Contact: Molly Quan mquan4@mgh.harvard.edu

  Location: 149 13^th Street, Charlestown, MA

• Vascular Pathology in Early and Asymptomatic Cerebral Angiopathy –This study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
  Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu

  Additional information: https://rally.partners.org/study/caamemorystudy
  Location: Mass General Hospital

• Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
  Contact Erin Krahn: ekrahn@mgh.harvard.edu

  Location: 149 13^th Street, Charlestown, MA 

• Resilient Together – A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
  Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu

• Additional information https://rally.partners.org/study/resilienttogether
  Location: 149 13^th Street, Charlestown, MA

 McLean Hospital
Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

Northeastern University Music-Based Intervention Research Study 
MBI Flyer
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com

Beth Israel Deaconess Medical Center

GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu