Join a Study
The MADRC research team is dedicated to finding a cure for Alzheimer’s disease and related dementias.
We offer many cutting-edge studies that are both federally and privately funded. Please see the list of studies seeking research participant volunteers below.
Have questions or need more information? Call us at 617-278-0600. We are here to help!
To learn more about different types of diagnoses click here.
Guide to Clinical Trials & Observational Studies
➡ Prevention
Prevention
AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid. Contact: (617) 278-0600. Additional information: www.studymemory.org Location: 60 Fenwood Road, Boston, MA
Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit. Contact: MemoryAndAging@mgh.harvard.edu Additional Information: MAC Flyer
➡ Cognitively Normal (Studies for people with no symptoms of memory loss or dementia)
Normal Cognition
BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment. Contact: cdfitzpatrick@bwh.harvard.edu
MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory & Aging Study Flyer
Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu Additional information: https://rally.massgeneralbrigham.org/study/memory_stress
Location: MGH Multicultural Alzheimer’s Prevention Program
APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org
Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning. Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13th Street, Charlestown, MA
Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases. Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA
Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit. Contact: MemoryAndAging@mgh.harvard.edu Additional Information: MAC Flyer
Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain. Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet Location:149 13th Street, Charlestown, MA
Normal Cognition Spanish Speaker
MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. Contact: robregongarcia@mgh.harvard.edu Additional Information: Spanish Memory & Aging Study Flyer
Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns.
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.massgeneralbrigham.org/study/memory_stress. Stress Study_Spanish Flyer Location: MGH Multicultural Alzheimer’s Prevention Program
Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional Information: BLAST Flyer Spanish
Location: 149 13th Street, Charlestown, MA
Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.partners.org/study/_latino_habs
Location: 149 13th Street, Charlestown, MA
Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu Additional Information: MAC Flyer Spanish
Sort by Diagnosis
You may be eligible if you have:
Subjective Cognitive Decline
MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. Contact: JJOHANSON1@mgh.harvard.edu Additional Information: Memory & Aging Study Flyer
Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.
Contact: Zoe Katz, zskatz@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_scd. Location: 149 13th Street, Charlestown, MA
Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or
Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet Location:149 13th Street, Charlestown, MA
Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA
Mild Cognitive Impairment
BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.
Contact: cdfitzpatrick@bwh.harvard.edu
MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. Contact: JJOHANSON1@mgh.harvard.edu Additional Information: Memory & Aging Study Flye
Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu Additional information: https://rally.massgeneralbrigham.org/study/memory_stress
Location: MGH Multicultural Alzheimer’s Prevention Program
Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu Additional information: https://rally.partners.org/study/study_iadl
Location:149 13th Street, Charlestown, MA
BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information:https://rally.massgeneralbrigham.org/study/bcg_in_ad
Location: 149 13th Street, Charlestown, MA
Sleep on Neural Networks in Brain Aging (SONNET) – A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or
Raina Levin,rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA
Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
Contact: Molly Lawrence (617) 726-3086 mlawrence9@bwh.harvard.edu
Additional information multimodal brochure
Location: 149 13th Street, Charlestown, MA
Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA
Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
Contact: pbm@mgh.harvard.edu
Additional Information:
https://rally.partners.org/study/trapad_study
Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body.
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu
Additional Information: https://rally.partners.org/study/novartis
Location: 149 13th Street, Charlestown, MA
Alzheimer's Disease
Cyclerion – an investigational medication that penetrates the central nervous system and increases the activity of a molecule pathway that affects neuronal function, controls neuronal inflammation, and vascular function.
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.massgeneralbrigham.org/study/cyclerion
Location: 149 13th Street, Charlestown, MA
NMN AD Study– Men and women aged 55-85 who are diagnosed with mild Alzheimer’s disease are invited to join our study which is investigating whether study drug MIB-626 can be beneficial for Alzheimer’s patients.
Contact: Bella Levesque, ilevesque@bwh.harvard.edu
Additional Information: Study Flyer
Location: 60 Fenwood Road Boston, MA 02115
BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad
Location: 149 13th Street, Charlestown, MA
Athira – a phase II study of ATH -1017, an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.partners.org/study/ath_1017
Location: 149 13th Street, Charlestown, MA
Memory Awareness AWARE –A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
Contact: Sharon Wang, swang72@mgh.harvard.edu
More information: https://rally.partners.org/study/the_memoryawareness_study
Location: 149 13th Street, Charlestown, MA
Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location: 149 13th Street, Charlestown, MA
Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
Contact: Molly Lawrence (617) 726-3086 mlawrence9@bwh.harvard.edu
Additional information Multimodal brochure
Location: 149 13th Street, Charlestown, MA
Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: Katherine Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA
Tau PET Imaging Study A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Longitudinal Early Onset Disease Study (LEADS)– A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
Additional information: LEADS flyer
Location: 149 13th Street, Charlestown, MA
JNJ Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.partners.org/study/johnsonandjohnson
Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.partners.org/study/novartis
Location: 149 13th Street, Charlestown, MA
➡ Frontotemporal Dementia
Frontotemporal Dementia
GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.
Contact: Hannah Bedrosian HBEDROSIAN@mgh.harvard.edu
LRTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Primary Progressive Aphasia
Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Posterior Cortical Atrophy
Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Progressive Supranuclear Palsy
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Cortical Basal Syndrome
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Lewy Body Dementia
Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease. Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA
Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA). Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA
Parkinson Disease Dementia
Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease. Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA
Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA). Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA
Vascular Dementia
- Vascular Pathology in Early and Asymptomatic Cerebral Angiopathy –This study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
Contact: Vanessa Gonzlaez vagonzalez@mgh.harvard.edu
Additional information: https://rally.partners.org/study/caamemorystudy
Location: Mass General Hospital
➡ Additional Studies
Spanish Speaker
- Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional Information: BLAST Flyer Spanish
Location: 149 13th Street, Charlestown, MA - Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.partners.org/study/_latino_habs
Location: 149 13th Street, Charlestown, MA
- Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu Additional Information: MAC Flyer Spanish
- MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. Contact: robregongarcia@mgh.harvard.edu Additional Information: Spanish Memory & Aging Study
Caregiver
- Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
Contact Erin Krahn: ekrahn@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA - Resilient Together – A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu
Additional information https://rally.partners.org/study/resilienttogether
Location: 149 13th Street, Charlestown, MA
Affiliate Research Studies Contact:
Northeastern University Music-Based Intervention Research Study
MBI Flyer
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com
McLean Hospital
Contact: Stefanie WONG SWONG18@PARTNERS.ORG
Beth Israel Deaconess Medical Center
GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.
Contact: Nainika Grover 617-667-0362 ngrover@bidmc.harvard.edu
Sort by Study Type
➡ A Drug or Intervention Trial
Prevention of Alzheimer’s Disease in Normal Adults
AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.
Contact: 617-278-0600
Additional information: : https://www.aheadstudy.org
Location: 60 Fenwood Road, Boston, MA
Patients with Mild Cognitive Impairment
BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad
Location: 149 13th Street, Charlestown, MA
Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
Contact: pbm@mgh.harvard.edu
Additional Information: https://rally.partners.org/study/trapad_study
Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu
Additional Information: https://rally.partners.org/study/novartis
Location: 149 13th Street, Charlestown, MA
Patients with Alzheimer’s Disease Dementia
Cyclerion – an investigational medication that penetrates the central nervous system and increases the activity of a molecule pathway that affects neuronal function, controls neuronal inflammation, and vascular function.
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.massgeneralbrigham.org/study/cyclerion Location: 149 13th Street, Charlestown, MA
NMN AD Study – Men and women aged 55-85 who are diagnosed with mild Alzheimer’s disease are invited to join our study which is investigating whether study drug MIB-626 can be beneficial for Alzheimer’s patients.
Contact: Bella Levesque, ilevesque@bwh.harvard.edu
Additional Information: Study Flyer Location: 60 Fenwood Road Boston, MA 02115
BCG vaccine -BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination. Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad Location: 149 13th Street, Charlestown, MA
Athira – a phase II study of ATH -1017 , an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-723-2351
Additional Information: https://rally.partners.org/study/ath_1017
Location: 149 13th Street, Charlestown, MA
JNJ Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-723-2351
Additional Information: https://rally.partners.org/study/johnsonandjohnson
Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-723-2351
Additional Information: https://rally.partners.org/study/novartis
Location: 149 13th Street, Charlestown, MA
Patients with Frontotemporal Dementia or Primary Progressive Aphasia
GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.
Contact:Hannah Bedrosian HBEDROSIAN@mgh.harvard.edu
Transcranial Magnetic Stimulation Study -This study evaluates use of repetitive transcranial magnetic stimulation to target areas of memory and language in patients with amnestic mild cognitive impairment and the logogenic or non-fluent variant of primary progressive aphasia.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Affiliate Research Studies Contact:
Northeastern University Music-Based Intervention Research Study
MBI Flyer
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com
McLean Hospital
Contact: Stefanie Wong SWONG18@PARTNERS.ORG
Beth Israel Deaconess Medical Center
GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.
Contact: Nainika Grover 617-667-0362 ngrover@bidmc.harvard.edu
➡ An Observational Study (no drug or intervention):
If you are Cognitively Normal (no memory loss or dementia):
BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.
Contact: cdfitzpatrick@bwh.harvard.edu
MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory & Aging Study Flyer
APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning. Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13th Street, Charlestown, MA
Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA
Alzheimer’s Disease EEG Sleep Study– A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13th Street, Charlestown, MA
Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu.
Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet Location:149 13th Street, Charlestown, MA
Cognitively Normal and a Spanish Speaker
MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. Contact: robregongarcia@mgh.harvard.edu Additional Information: Spanish Memory & Aging Study
Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional Information: BLAST Flyer Spanish
Location: 149 13th Street, Charlestown, MA
Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.partners.org/study/_latino_habs
Location: 149 13th Street, Charlestown, MA
Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Older Adults Concerned About Their Memory (Subjective Cognitive Decline)
MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. Contact: JJOHANSON1@mgh.harvard.edu Additional Information: Memory & Aging Study Flyer
Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.
Contact: Zoe Katz, zskatz@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_scd
Location: 149 13th Street, Charlestown, MA.
Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet Location:149 13th Street, Charlestown, MA
Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA
Patients with Mild Cognitive Impairment
BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment. Contact: cdfitzpatrick@bwh.harvard.edu
MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. Contact: JJOHANSON1@mgh.harvard.edu Additional Information: Memory & Aging Study Flyer
Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu Additional information: https://rally.partners.org/study/study_iadl Location: 149 13th Street, Charlestown, MA
Sleep on Neural Networks in Brain Aging (SONNET) –A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA
Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
Contact: Molly Lawrence (617) 726-3086 mlawrence9@bwh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA
Alzheimer’s Disease EEG Sleep Study– A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/risk_of_alzheimers
Location: 149 13th Street, Charlestown, MA
Patients with Alzheimer’s Disease Dementia
Memory Awareness – A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
Contact: Sharon Wang, swang72@mgh.harvard.edu Additional info: https://rally.partners.org/study/the_memoryawareness_study. Location: 149 13th Street, Charlestown, MA
Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu
Additional information https://rally.partners.org/study/sonnet
Location: 149 13th Street, Charlestown, MA
Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
Contact: Molly Lawrence (617) 726-3086 mlawrence9@bwh.harvard.edu
Additional information: Multimodal flyer
Location: 149 13th Street, Charlestown, MA
Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu (617) 643-4802 Additional information: https://rally.partners.org/study/lifespan_biobank. Location: 149 13th Street, Charlestown, MA
Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Longitudinal Early Onset Disease Study (LEADS)– A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
Additional information: AA_LEADS-Brochure_
Location: 149 13th Street, Charlestown, MA
Alzheimer’s Disease EEG Sleep Study– A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13th Street, Charlestown, MA
Resilient Together Study- A study seeking to understand the experiences, needs, and preferences of individuals with a form of young onset dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
Contact: Paula Popok 617-724-0051 ppopok@mgh.harvard.edu
Additional information: https://rally.partners.org/study/resilienttogether
Location: 149 13th Street, Charlestown, MA
Dementia, Care Planning and Surgery -This is a study to help understand the effectiveness of advance care planning for participants with dementia and either considering or considered surgery.
Contact: Stephen Perez: sperez14@bwh.harvard.edu (617) 732-6176
Additional information: https://rally.partners.org/study/careplanningdementia
Location: 60 Fenwood Road, Boston, MA
Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Patients with Frontotemporal Dementia, Primary Progressive Aphasia, Posterior Cortical Atrophy, Progressive Supranuclear Palsy or Corticobasal Syndrome
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)– A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Patients with Lewy Body Dementia or Parkinson’s Disease with Dementia
Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease. Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA
Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA). Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA
Patients with Vascular Disease and Cerebral Amyloid Angiopathy
Vascular Pathology in Early and Asymptomatic Cerebral Angiopathy –This study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu
Additional information: https://rally.partners.org/study/caamemorystudy
Location: Mass General Hospital
A Caregiver
Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
Contact Erin Krahn: ekrahn@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA
Resilient Together – A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu
Additional information https://rally.partners.org/study/resilienttogether
Location: 149 13th Street, Charlestown, MA
Affiliated research partner studies contact:
McLean Hospital
Contact: Stefanie Wong SWONG18@PARTNERS.ORG
Northeastern University Music-Based Intervention Research Study
MBI Flyer
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com
Beth Israel Deaconess Medical Center
GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.
Contact: Nainika Grover 617-667-0362 ngrover@bidmc.harvard.edu
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