Join a Study

The MADRC research  team is dedicated to finding a cure for Alzheimer’s disease and related dementias.

We offer many cutting-edge studies that are both federally and privately funded. Please see the list of studies seeking research participant volunteers below.

Have questions or need more information?  Call us at 617-278-0600.  We are here to help!

To learn more about different types of diagnoses click here.

Guide to Clinical Trials & Observational Studies

➡ Prevention

Prevention

AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.                                                                     Contact: (617) 278-0600.                                                                                                              Additional information: www.studymemory.org                                                          Location:  60 Fenwood Road, Boston, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.           Contact: MemoryAndAging@mgh.harvard.edu                                                              Additional Information: MAC Flyer

➡ Cognitively Normal (Studies for people with no symptoms of memory loss or dementia)

Normal Cognition

BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.                                                                                  Contact: cdfitzpatrick@bwh.harvard.edu                                                                      

MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                             Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory & Aging Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu                      Additional information: https://rally.massgeneralbrigham.org/study/memory_stress
Location: MGH Multicultural Alzheimer’s Prevention Program

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org

Instrumental Activities of Daily Living (IADL) A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.                                                        Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu                                              Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13th Street, Charlestown, MA

Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.                                                                                                      Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.          Contact: MemoryAndAging@mgh.harvard.edu                                                                 Additional Information: MAC Flyer

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.                                                                                                                      Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet                            Location:149 13th Street, Charlestown, MA

    Normal Cognition Spanish Speaker

    MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                            Contactrobregongarcia@mgh.harvard.edu                                                                      Additional Information: Spanish Memory & Aging Study Flyer

    Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns.                  

    Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
    Additional information: https://rally.massgeneralbrigham.org/study/memory_stress.                                   Stress Study_Spanish Flyer                                                                                                          Location: MGH Multicultural Alzheimer’s Prevention Program

    Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
    Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
    Additional Information: BLAST Flyer Spanish
    Location: 149 13th Street, Charlestown, MA

    Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
    Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/_latino_habs
    Location: 149 13th Street, Charlestown, MA

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    Contact: MemoryAndAging@mgh.harvard.edu                                                                 
    Additional Information: MAC Flyer Spanish

     

    Sort by Diagnosis

    You may be eligible if you have:

    Subjective Cognitive Decline

    MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                             Contact: JJOHANSON1@mgh.harvard.edu                                                                      Additional Information: Memory & Aging Study Flyer

    Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.
    Contact: Zoe Katz,  zskatz@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/study_scd.                     Location: 149 13th Street, Charlestown, MA

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.

    Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or
    Raina Levin, rlevin4@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/sonnet                          Location:149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
    Contact:
    KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/lifespan_biobank
    Location: 149 13th Street, Charlestown, MA

     

    Mild Cognitive Impairment

    BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.                                                                                              

    Contact: cdfitzpatrick@bwh.harvard.edu   

    MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                            Contact: JJOHANSON1@mgh.harvard.edu                                                          Additional Information: Memory & Aging Study Flye

    Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns

    Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu                        Additional information: https://rally.massgeneralbrigham.org/study/memory_stress
    Location: MGH Multicultural Alzheimer’s Prevention Program

    Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.

    Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu                                              Additional information: https://rally.partners.org/study/study_iadl
    Location:149 13th Street, Charlestown, MA

    BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information:https://rally.massgeneralbrigham.org/study/bcg_in_ad

    Location: 149 13th Street, Charlestown, MA   

    Sleep on Neural Networks in Brain Aging (SONNET) – A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.

    Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu  or
    Raina Levin,rlevin4@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/sonnet
    Location:149 13th Street, Charlestown, MA

    Multimodal investigation of hyperexcitability in Alzheimer’s diseaseA study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.

    Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
    Additional information multimodal brochure
    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.

    Contact:  KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/lifespan_biobank
    Location: 149 13th Street, Charlestown, MA

    Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85

    Contact: pbm@mgh.harvard.edu
    Additional Information:
    https://rally.partners.org/study/trapad_study

    Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

    Contact: MemoryAndAging@mgh.harvard.edu

    Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body.

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu
    Additional Information: https://rally.partners.org/study/novartis
    Location: 149 13th Street, Charlestown, MA

     

    Alzheimer's Disease

    Cyclerion – an investigational medication that penetrates the central nervous system and increases the activity of a molecule pathway that affects neuronal function, controls neuronal inflammation, and vascular function.
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/cyclerion

    Location: 149 13th Street, Charlestown, MA     

    NMN AD Study– Men and women aged 55-85 who are diagnosed with mild Alzheimer’s disease are invited to join our study which is investigating whether study drug MIB-626 can  be beneficial for Alzheimer’s patients.

    Contact: Bella Levesque, ilevesque@bwh.harvard.edu
    Additional Information: Study Flyer

    Location: 60 Fenwood Road Boston, MA 02115

    BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination. 

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad

    Location: 149 13th Street, Charlestown, MA    

    Athira – a phase II study of ATH -1017, an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Informationhttps://rally.partners.org/study/ath_1017
    Location: 149 13th Street, Charlestown, MA                                                             

    Memory Awareness AWAREA study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
    Contact: Sharon Wang, swang72@mgh.harvard.edu

    More information: https://rally.partners.org/study/the_memoryawareness_study
    Location: 149 13th Street, Charlestown, MA

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
    Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu
    Additional information:  https://rally.partners.org/study/sonnet
    Location: 149 13th Street, Charlestown, MA

    Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
    Contact:
    Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
    Additional information Multimodal brochure
    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
    Contact: Katherine Cropp,  KCROPP1@mgh.harvard.edu 617-643-4802
    Additional information: https://rally.partners.org/study/lifespan_biobank
    Location: 149 13th Street, Charlestown, MA

    Tau PET Imaging Study A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
    Location: 149 13th Street, Charlestown, MA

    Longitudinal Early Onset Disease Study (LEADS) A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
    Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
    Additional information: LEADS flyer
    Location: 149 13th Street, Charlestown, MA

     

    JNJ Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
    Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.partners.org/study/johnsonandjohnson

    Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    Contact: MemoryAndAging@mgh.harvard.edu

    Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.partners.org/study/novartis
    Location: 149 13th Street, Charlestown, MA

     

    ➡ Frontotemporal Dementia

    Frontotemporal Dementia

    GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.                      

    Contact: Hannah Bedrosian HBEDROSIAN@mgh.harvard.edu

    LRTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      

    Contact: Erin Krahn, ekrahn@mgh.harvard.edu

     

    Primary Progressive Aphasia

    Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA 

    ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      

    Contact: Erin Krahn, ekrahn@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA

    Posterior Cortical Atrophy

    Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA 

    Progressive Supranuclear Palsy

    ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      

    Contact: Erin Krahn, ekrahn@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA

    4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
    Location: 149 13th Street, Charlestown, MA

    Cortical Basal Syndrome

     

    ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      

    Contact: Erin Krahn, ekrahn@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA

    4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.

    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
    Location: 149 13th Street, Charlestown, MA

    Lewy Body Dementia

    Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease. Contact: Anna Goodheart agoodheart@partners.org

    Location: 149 13th Street, Charlestown, MA

     

    Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA). Contact: Anna Goodheart agoodheart@partners.org

    Location: 149 13th Street, Charlestown, MA

    Parkinson Disease Dementia

    Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease. Contact: Anna Goodheart agoodheart@partners.org

    Location: 149 13th Street, Charlestown, MA

     

    Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA). Contact: Anna Goodheart agoodheart@partners.org

    Location: 149 13th Street, Charlestown, MA

    Vascular Dementia

    • Vascular Pathology in Early and Asymptomatic Cerebral AngiopathyThis study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
      Contact: Vanessa Gonzlaez vagonzalez@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/caamemorystudy
      Location: Mass General Hospital

    ➡ Additional Studies

    Spanish Speaker

    • Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
      Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
      Additional InformationBLAST Flyer Spanish
      Location: 149 13th Street, Charlestown, MA
    •  
    • Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
      Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/_latino_habs
      Location: 149 13th Street, Charlestown, MA

    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
      Contact: MemoryAndAging@mgh.harvard.edu                                                                 
      Additional Information: MAC Flyer Spanish

    • MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                                                                               Contactrobregongarcia@mgh.harvard.edu                                                                Additional Information: Spanish Memory & Aging Study

       

    Caregiver

    • Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
      Contact Erin Krahn: ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA
    •  
    • Resilient Together A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
      Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu
      Additional information https://rally.partners.org/study/resilienttogether
      Location: 149 13th Street, Charlestown, MA

    Affiliate Research Studies Contact:

    Northeastern University Music-Based Intervention Research Study
    MBI Flyer 
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com 

    McLean Hospital
    Contact: Stefanie WONG SWONG18@PARTNERS.ORG

    Beth Israel Deaconess Medical Center

    GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

    Sort by Study Type

    ➡ A Drug or Intervention Trial

    Prevention of Alzheimer’s Disease in Normal Adults

     

    AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.
    Contact: 617-278-0600
    Additional information: : https://www.aheadstudy.org
    Location:  60 Fenwood Road, Boston, MA

    Patients with Mild Cognitive Impairment

     BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad

    Location: 149 13th Street, Charlestown, MA   

    Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85

    Contact: pbm@mgh.harvard.edu

    Additional Information: https://rally.partners.org/study/trapad_study 

     Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu

    Additional Information: https://rally.partners.org/study/novartis

    Location: 149 13th Street, Charlestown, MA

    Patients with Alzheimer’s Disease Dementia

    Cyclerion – an investigational medication that penetrates the central nervous system and increases the activity of a molecule pathway that affects neuronal function, controls neuronal inflammation, and vascular function.
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/cyclerion Location: 149 13th Street, Charlestown, MA

    NMN AD Study – Men and women aged 55-85 who are diagnosed with mild Alzheimer’s disease are invited to join our study which is investigating whether study drug MIB-626 can  be beneficial for Alzheimer’s patients.

    Contact: Bella Levesque, ilevesque@bwh.harvard.edu
    Additional Information: Study Flyer                                                                                      Location: 60 Fenwood Road Boston, MA 02115

    BCG vaccine -BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.                                                      Contact: Kate Cropp, KCROPP1@mgh.harvard.edu  617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad Location: 149 13th Street, Charlestown, MA   

    Athira – a phase II study of ATH -1017 , an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu   617-723-2351
    Additional Information: https://rally.partners.org/study/ath_1017

    Location: 149 13th Street, Charlestown, MA

    JNJ Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
    Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-723-2351
    Additional Information:
    https://rally.partners.org/study/johnsonandjohnson

    Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-723-2351
    Additional Information:  https://rally.partners.org/study/novartis
    Location: 149 13th Street, Charlestown, MA

    Patients with Frontotemporal Dementia or Primary Progressive Aphasia

    GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.                      

    Contact:Hannah Bedrosian HBEDROSIAN@mgh.harvard.edu

    Transcranial Magnetic Stimulation Study -This study evaluates use of repetitive transcranial magnetic stimulation to target areas of memory and language in patients with amnestic mild cognitive impairment and the logogenic or non-fluent variant of primary progressive aphasia.
    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
    Location: 149 13th Street, Charlestown, MA

    Affiliate Research Studies Contact:

    Northeastern University Music-Based Intervention Research Study
    MBI Flyer 
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com

    McLean Hospital
    Contact: Stefanie Wong SWONG18@PARTNERS.ORG

    Beth Israel Deaconess Medical Center

    GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

     

     

    ➡ An Observational Study (no drug or intervention):

    If you are Cognitively Normal (no memory loss or dementia):

    BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.                                                                                                            

    Contact: cdfitzpatrick@bwh.harvard.edu  

    MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                                                                                   
    Contact: JJOHANSON1@mgh.harvard.edu                                                           
    Additional Information: Memory & Aging Study  Flyer

    APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.

    www.aptwebstudy.org

    Instrumental Activities of Daily Living (IADL) A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.                                                        Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/study_iadl

    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.

    Contact: KCROPP1@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/lifespan_biobank

    Location: 149 13th Street, Charlestown, MA

    Alzheimer’s Disease EEG Sleep Study   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.

    Contact: purdonlab@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/noninvasive_biomarkers

    Location: 149 13th Street, Charlestown, MA 

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

    Contact: MemoryAndAging@mgh.harvard.edu.                                                                                                   

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.

    Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/sonnet                          Location:149 13th Street, Charlestown, MA

    Cognitively Normal and a Spanish Speaker

    MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                             Contactrobregongarcia@mgh.harvard.edu                                                                  Additional Information: Spanish Memory & Aging Study

    Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.

    Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu

    Additional Information: BLAST Flyer Spanish

    Location: 149 13th Street, Charlestown, MA

    Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.

    Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/_latino_habs

    Location: 149 13th Street, Charlestown, MA

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

    Contact: MemoryAndAging@mgh.harvard.edu

    Older Adults Concerned About Their Memory (Subjective Cognitive Decline)

    MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                            Contact: JJOHANSON1@mgh.harvard.edu                                                          Additional Information: Memory & Aging Study  Flyer

    Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.

    Contact: Zoe Katz, zskatz@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/study_scd

    Location: 149 13th Street, Charlestown, MA.   

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.

    Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu  or Raina Levin, rlevin4@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/sonnet                          Location:149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.

    Contact: KCROPP1@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/lifespan_biobank

    Location: 149 13th Street, Charlestown, MA

    Patients with Mild Cognitive Impairment

    BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.                                                                                              Contact: cdfitzpatrick@bwh.harvard.edu  

    MADRC Memory & Aging Study: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                          Contact: JJOHANSON1@mgh.harvard.edu                                                          Additional Information: Memory & Aging Study  Flyer

    Instrumental Activities of Daily Living (IADL)A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.

    Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu                                      Additional information: https://rally.partners.org/study/study_iadl               Location: 149 13th Street, Charlestown, MA

    Sleep on Neural Networks in Brain Aging (SONNET)A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.

    Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/sonnet

    Location:149 13th Street, Charlestown, MA

    Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.

    Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu

    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.

    Contact: KCROPP1@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/lifespan_biobank

    Location: 149 13th Street, Charlestown, MA

    Alzheimer’s Disease EEG Sleep Study  A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).

    Contact: purdonlab@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/risk_of_alzheimers

    Location: 149 13th Street, Charlestown, MA     

    Patients with Alzheimer’s Disease Dementia

    Memory Awareness – A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.

    Contact: Sharon Wang, swang72@mgh.harvard.edu                                              Additional info:               https://rally.partners.org/study/the_memoryawareness_study.                           Location: 149 13th Street, Charlestown, MA

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.

    Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu

    Additional information https://rally.partners.org/study/sonnet

    Location: 149 13th Street, Charlestown, MA

    Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.

    Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu

    Additional information: Multimodal flyer

    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.

    Contact: KCROPP1@mgh.harvard.edu   (617) 643-4802                                         Additional information: https://rally.partners.org/study/lifespan_biobank. Location: 149 13th Street, Charlestown, MA

    Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.

    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA

    Longitudinal Early Onset Disease Study (LEADS) A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.

    Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu

    Additional information: AA_LEADS-Brochure_

    Location: 149 13th Street, Charlestown, MA

    Alzheimer’s Disease EEG Sleep Study   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).

    Contact: purdonlab@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/noninvasive_biomarkers

    Location: 149 13th Street, Charlestown, MA 

    Resilient Together Study- A study seeking to understand the experiences, needs, and preferences of individuals with a form of young onset dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.

    Contact: Paula Popok 617-724-0051 ppopok@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/resilienttogether

    Location: 149 13th Street, Charlestown, MA

    Dementia, Care Planning and Surgery -This is a study to help understand the effectiveness of advance care planning for participants with dementia and either considering or considered surgery.

    Contact: Stephen Perez: sperez14@bwh.harvard.edu  (617) 732-6176

    Additional information: https://rally.partners.org/study/careplanningdementia

    Location:  60 Fenwood Road, Boston, MA

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

    Contact: MemoryAndAging@mgh.harvard.edu

     

    Patients with Frontotemporal Dementia, Primary Progressive Aphasia, Posterior Cortical Atrophy, Progressive Supranuclear Palsy or Corticobasal Syndrome

    ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)– A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.

    Contact: Erin Krahn, ekrahn@mgh.harvard.edu

    Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.

    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA

    4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.

    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA

    Patients with Lewy Body Dementia or Parkinson’s Disease with Dementia

    Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease. Contact: Anna Goodheart agoodheart@partners.org

    Location: 149 13th Street, Charlestown, MA

     

    Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA). Contact: Anna Goodheart agoodheart@partners.org

    Location: 149 13th Street, Charlestown, MA

     

    Patients with Vascular Disease and Cerebral Amyloid Angiopathy

    Vascular Pathology in Early and Asymptomatic Cerebral AngiopathyThis study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.

    Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/caamemorystudy

    Location: Mass General Hospital

    A Caregiver

    Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.

    Contact Erin Krahn: ekrahn@mgh.harvard.edu

    Location: 149 13th Street, Charlestown, MA

    Resilient Together A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.

    Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu

    Additional information https://rally.partners.org/study/resilienttogether

    Location: 149 13th Street, Charlestown, MA

    Affiliated research partner studies contact:

     McLean Hospital
    Contact: Stefanie Wong  SWONG18@PARTNERS.ORG

    Northeastern University Music-Based Intervention Research Study 
    MBI Flyer
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com

    Beth Israel Deaconess Medical Center

    GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

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