Join a Study

The MADRC research  team is dedicated to finding a cure for Alzheimer’s disease and related dementias.    If you need additional information or have questions, call us at 617-525-3666. We are here to help!

We offer several cutting-edge studies that are both federally and privately funded. Please see the list of available studies below.

To learn more about different types of diagnoses click here.

Guide to Clinical Trials & Observational Studies

➡ Prevention

Prevention

AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.

Contact: (617) 278-0600.                                                                                                            Additional information: https://www.aheadstudy.org                                                                  Location:  60 Fenwood Road, Boston, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

Contact: MemoryAndAging@mgh.harvard.edu

Additional Information:MAC Study Flyer

➡ Cognitively Normal (Studies for people with no symptoms of memory loss or dementia)

Click to enlarge

Normal Cognition

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org

Locust Study – Tracking the Origin of Tau Pathology: This study will help researchers distinguish healthy brain aging compared to brain changes in individuals with brain diseases such as Alzheimer’s disease (AD). This observational study is for cognitively healthy participants ages 36-56. Individuals will be asked to complete cognitive testing, MRI scans, blood draws and PET scans to help researchers understand the structure and function of the locus coeruleus, one of the first sites to harbor tau pathology in the brain. This study has 8 visits over 3 years.

Contact : Nina Engels, NENGELS@mgh.harvard.edu

Additional information: Locust Study

Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently used by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/actru_bcg_pilot.
Location: 149 13th Street, Charlestown, MA

Instrumental Activities of Daily Living (IADL) A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu

Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13th Street, Charlestown, MA

Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.
Contact: Sam Huang shuang27@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study Flyer

     

    Normal Cognition Spanish Speaker

    Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
    Contact: Jairo Martinez  jmartinez24@mgh.harvard.edu
    Additional Information: BLAST Flyer Spanish
    Location: 149 13th Street, Charlestown, MA

     

    Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
    Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/_latino_habs
    Location: 149 13th Street, Charlestown, MA

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    Contact: MemoryAndAging@mgh.harvard.edu

    Additional Information: MAC Study Flyer

     

     

     

    Click to enlarge

    Sort by Diagnosis

    You may be eligible if you have:

    Subjective Cognitive Decline

    Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.
    Contact: Colleen Fitzpatrick, cdfitzpatrick@bwh.harvard.edu
    Additional information: https://rally.partners.org/study/study_scd.              Location: 149 13th Street, Charlestown, MA

     

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
    Contact: Nick Stevenson, nestevenson@mgh.harvard.edu                                          Additional information: https://rally.partners.org/study/sonnet                          Location:149 13th Street, Charlestown, MA

     

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
    Contact:
    KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/lifespan_biobank 
    Location: 149 13th Street, Charlestown, MA

     

    Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently aused by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
    Contact: KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/actru_bcg_pilot
    Location: 149 13th Street, Charlestown, MA

     

     

     

     

     

     

     

    Mild Cognitive Impairment

    Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently used by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
    Contact: KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/actru_bcg_pilot
    Location: 149 13th Street, Charlestown, MA

    Niagen Study -A pilot study for the use of nicotinamide riboside (an alternative form of B3) which works in the body to help convert food to energy and repair damaged DNA. This study will evaluate its effect on cognitive and behavioral symptoms.
    Contact: KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/pactad_niagen
    Location: 149 13th Street, Charlestown, MA

    Instrumental Activities of Daily Living (IADL
    ) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
    Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu

    Additional information: https://rally.partners.org/study/study_iadl
    Location:149 13th Street, Charlestown, MA

    Sleep on Neural Networks in Brain Aging (SONNET) – A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
    Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/sonnet
    Location:149 13th Street, Charlestown, MA

    Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
    Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
    Additional information multimodal brochure
    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
    Contact:  KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/lifespan_biobank
    Location: 149 13th Street, Charlestown, MA

    Alzheimer’s Disease EEG Sleep Study–   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
    Contact: Sam Huang shuang27@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/risk_of_alzheimers
    Location: 149 13th Street, Charlestown, MA

    Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
    Contact: pbm@mgh.harvard.edu
    Additional Information:
    https://rally.partners.org/study/trapad_study

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    Contact: MemoryAndAging@mgh.harvard.edu
    Additional Information: MAC Study Flyer

     

     

    Alzheimer's Disease

    Athira – a phase II study of ATH -1017, an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-723-2351
    Additional Informationhttps://rally.partners.org/study/ath_1017
    Location: 149 13th Street, Charlestown, MA                                                                   

    Memory AwarenessA study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
    Contact: Sharon Wang, swang72@mgh.harvard.edu

    More information: https://rally.partners.org/study/the_memoryawareness_study
    Location: 149 13th Street, Charlestown, MA

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
    Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
    Additional information:  https://rally.partners.org/study/sonnet
    Location: 149 13th Street, Charlestown, MA

    Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
    Contact:
    Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
    Additional information Multimodal brochure
    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
    Contact: Katherine Cropp,  KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/lifespan_biobank
    Location: 149 13th Street, Charlestown, MA

    Tau PET Imaging Study A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
    Location: 149 13th Street, Charlestown, MA

    Longitudinal Early Onset Disease Study (LEADS) A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
    Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
    Additional information: LEADS flyer
    Location: 149 13th Street, Charlestown, MA

    Alzheimer’s Disease EEG Sleep Study   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
    Contact: Sam Huang shuang27@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/noninvasive_biomarkers
    Location: 149 13th Street, Charlestown, MA

    Resilient Together Study A study seeking to understand the experiences, needs, and preferences of individuals with a form of young onset dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
    Contact: Paula Popok 617-724-0051 ppopok@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/resilienttogether
    Location: 149 13th Street, Charlestown, MA

    Dementia, Care Planning and Surgery -This is a study to help understand the effectiveness of advance care planning for participants with dementia and either considering or considered surgery.
    Contact: Stephen Perez: 617-732-6176 sperez14@bwh.harvard.edu
    Additional information: https://rally.partners.org/study/careplanningdementia
    Location:  60 Fenwood Road, Boston, MA

    Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
    Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-723-2351
    Additional Information: https://rally.partners.org/study/johnsonandjohnson

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    Contact: MemoryAndAging@mgh.harvard.edu

    Additional Information: MAC Study Flyer

     

     

     

     

     

     

     

     

     

     

     

     

     

     

    Click to enlarge

    ➡ Frontotemporal Dementia

    Frontotemporal Dementia

    • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      Contact: Erin Krahn, ekrahn@mgh.harvard.edu

    Primary Progressive Aphasia

    • Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu

         Location: 149 13th Street, Charlestown, MA 

    • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, a family member with medical history of FTD.
      Contact: Erin Krahn, ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Posterior Cortical Atrophy

    • Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Progressive Supranuclear Palsy

     

    • 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA 
    • AARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
      Contact: Erin Krahn, ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Cortical Basal Syndrome

    • 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

       

    • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
      Contact: Erin Krahn, ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Lewy Body Dementia

    • Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease.
      Contact: Molly Quan mquan4@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

       

    • Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
      Contact: Molly Quan mquan4@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Parkinson Disease Dementia

    • Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease.
      Contact: Molly Quan mquan4@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA
    •  
    • Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
      Contact: Molly Quan mquan4@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Vascular Dementia

    • Vascular Pathology in Early and Asymptomatic Cerebral AngiopathyThis study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
      Contact: Vanessa Gonzlaez vagonzalez@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/caamemorystudy
      Location: Mass General Hospital

    ➡ Additional Studies

    Spanish Speaker

    • Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
      Contact: Jairo Martinez  jmartinez24@mgh.harvard.edu
      Additional InformationBLAST Flyer Spanish
      Location: 149 13th Street, Charlestown, MA
    •  
    • Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
      Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/_latino_habs
      Location: 149 13th Street, Charlestown, MA

    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
      Contact: MemoryAndAging@mgh.harvard.edu

      Additional Information: MAC Study Flyer 

    • MADRC Memory & Aging Study: An observational study for participants 65 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain. 

        Contact: jjohanson1@mgh.harvard.edu

        Additional Information: Memory & Aging Study Flyer

    Caregiver

    • Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
      Contact Erin Krahn: ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA
    •  
    • Resilient Together A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
      Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu
      Additional information https://rally.partners.org/study/resilienttogether
      Location: 149 13th Street, Charlestown, MA

    Affiliate Research Studies Contact:

     

    Northeastern University Music-Based Intervention Research Study
    MBI Flyer 
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com 

    McLean Hospital
    Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

    Beth Israel Deaconess Medical Center
    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

     

     

    Sort by Study Type

    ➡ A Drug or Intervention Trial

    Prevention of Alzheimer’s Disease in Normal Adults

    • AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.
      Contact: 617-278-0600
      Additional information: : https://www.aheadstudy.org
      Location:  60 Fenwood Road, Boston, MA

    Older Adults Concerned About Their Memory (Subjective Cognitive Decline)

    • Niagen Study -A pilot study for the use of nicotinamide riboside (an alternative form of B3) which works in the body to help convert food to energy and repair damaged DNA. This study will evaluate its effect on cognitive and behavioral symptoms.
      Contact
      KCROPP1@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/pactad_niagen
      Location: 149 13th Street, Charlestown, MA
    • Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently used by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
      Contact:
      KCROPP1@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/actru_bcg_pilot
      Location: 149 13th Street, Charlestown, MA

    Patients with Mild Cognitive Impairment

     

    • Niagen Study -A pilot study for the use of nicotinamide riboside (an alternative form of B3) which works in the body to help convert food to energy and repair damaged DNA. This study will evaluate its effect on cognitive and behavioral symptoms.Contact: KCROPP1@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/pactad_niagen
      Location: 149 13th Street, Charlestown, MA

     

    • Bacillus Calmette-Guerin (BCG) vaccine study: A study for cognitively normal individuals 55- 80 years old. To determine if BCG vaccine can possibly help with inflammation and brain function. This vaccine is currently used by UNICEF and WHO as a standard vaccination for Tuberculosis. Japan BCG vaccine identified potential effects on T-cells in the immune system that help maintain homeostasis in immune response, possibly minimizing inflammation. This study is looking at how it may affect brain function.
      Contact: KCROPP1@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/actru_bcg_pilot
      Location: 149 13th Street, Charlestown, MA

     

    • Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
      Contact: pbm@mgh.harvard.edu
      Additional Information:
      https://rally.partners.org/study/trapad_study

    Patients with Alzheimer’s Disease Dementia

    • Athira – a phase II study of ATH -1017 , an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
      Contact: Kate Cropp, KCROPP1@mgh.harvard.edu   617-723-2351
      Additional Information: https://rally.partners.org/study/ath_1017

      Location: 149 13th Street, Charlestown, MA

    • Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
      Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-723-2351
      Additional Information: https://rally.partners.org/study/johnsonandjohnson

    Patients with Frontotemporal Dementia or Primary Progressive Aphasia

    • Transcranial Magnetic Stimulation Study -This study evaluates use of repetitive transcranial magnetic stimulation to target areas of memory and language in patients with amnestic mild cognitive impairment and the logogenic or non-fluent variant of primary progressive aphasia.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Patients with Lewy Body Dementia or Parkinson’s Disease with Dementia

    • Check back soon

    Affiliate Research Studies Contact:

    Northeastern University Music-Based Intervention Research Study
    MBI Flyer 
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com

    McLean Hospital
    Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

    Beth Israel Deaconess Medical Center
    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

     

    ➡ An Observational Study (no drug or intervention):

    If you are Cognitively Normal (no memory loss or dementia):

    • APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
      www.aptwebstudy.org
    • Locust Study – Tracking the Origin of Tau Pathology: This study will help researchers distinguish healthy brain aging compared to brain changes in individuals with brain diseases such as Alzheimer’s disease (AD). This observational study is for cognitively healthy participants ages 36-56. Individuals will be asked to complete cognitive testing, MRI scans, blood draws and PET scans to help researchers understand the structure and function of the locus coeruleus, one of the first sites to harbor tau pathology in the brain. This study has 8 visits over 3 years.
    • Contact : Nina Engels, NENGELS@mgh.harvard.edu
      Additional information: Locust Study

    • Instrumental Activities of Daily Living (IADL) A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.
      Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu

         Additional information: https://rally.partners.org/study/study_iadl
         Location: 149 13th Street, Charlestown, MA 

    • Alzheimer’s Disease EEG Sleep Study   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.
      Contact: Sam Huang shuang27@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/noninvasive_biomarkers
      Location: 149 13th Street, Charlestown, MA 

    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
      Contact: MemoryAndAging@mgh.harvard.edu.

         Additional Information: MAC Study Flyer

    Cognitively Normal and a Spanish Speaker

    • Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
    • Contact: Jairo Martinez | jmartinez24@mgh.harvard.edu
    • Additional Information: BLAST Flyer Spanish
    • Location: 149 13th Street, Charlestown, MA 
    • Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
    • Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/_latino_habs
      Location: 149 13th Street, Charlestown, MA
    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
      Contact: MemoryAndAging@mgh.harvard.edu
      Additional Information: MAC Study Flyer

    Older Adults Concerned About Their Memory (Subjective Cognitive Decline)

    Patients with Mild Cognitive Impairment

    • Instrumental Activities of Daily Living (IADL)A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
      Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu 

         Additional information: https://rally.partners.org/study/study_iadl

         Location: 149 13th Street, Charlestown, MA 

    • Sleep on Neural Networks in Brain Aging (SONNET)A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
      Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/sonnet
      Location:149 13th Street, Charlestown, MA 
    • Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
      Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
      Location: 149 13th Street, Charlestown, MA 
    • Alzheimer’s Disease EEG Sleep Study  A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
      Contact: Sam Huang shuang27@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/risk_of_alzheimers
      Location: 149 13th Street, Charlestown, MA.                                                                      

                                                        

    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    • Contact: MemoryAndAging@mgh.harvard.edu
      Additional Information: MAC Study Flyer 

    Patients with Alzheimer’s Disease Dementia

    • Memory Awareness – A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
      Contact: Sharon Wang, swang72@mgh.harvard.edu

          Additional info:                  https://rally.partners.org/study/the_memoryawareness_study
          Location: 149 13th Street, Charlestown, MA 

     

    • Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
      Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
      Additional information https://rally.partners.org/study/sonnet
      Location: 149 13th Street, Charlestown, MA 

     

    • Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
      Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
      Additional information: Multimodal flyer
      Location: 149 13th Street, Charlestown, MA 

     

     

    • Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

     

    • Longitudinal Early Onset Disease Study (LEADS) A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
      Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
      Additional information: AA_LEADS-Brochure_
      Location: 149 13th Street, Charlestown, MA

     

    • Alzheimer’s Disease EEG Sleep Study   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
      Contact: Sam Huang shuang27@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/noninvasive_biomarkers
      Location: 149 13th Street, Charlestown, MA 

     

    • Resilient Together Study- A study seeking to understand the experiences, needs, and preferences of individuals with a form of young onset dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
      Contact: Paula Popok 617-724-0051 ppopok@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/resilienttogether
      Location: 149 13th Street, Charlestown, MA

     

    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
      Contact: MemoryAndAging@mgh.harvard.edu
      Additional Information: MAC Study Flyer

     

    Patients with Frontotemporal Dementia, Primary Progressive Aphasia, Posterior Cortical Atrophy, Progressive Supranuclear Palsy or Corticobasal Syndrome

    • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)– A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
      Contact:
      Erin Krahn, ekrahn@mgh.harvard.edu

     

    • Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

     

    • 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

     

     

     

    Patients with Lewy Body Dementia or Parkinson’s Disease with Dementia

      • Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease. Contact: Molly Quan mquan4@mgh.harvard.edu

        Location: 149 13th Street, Charlestown, MA

      • Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
        Contact: Molly Quan mquan4@mgh.harvard.edu

        Location: 149 13th Street, Charlestown, MA

    Patients with Vascular Disease and Cerebral Amyloid Angiopathy

    • Vascular Pathology in Early and Asymptomatic Cerebral AngiopathyThis study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
      Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu

      Additional information: https://rally.partners.org/study/caamemorystudy
      Location: Mass General Hospital

    A Caregiver

    • Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
      Contact Erin Krahn: ekrahn@mgh.harvard.edu

      Location: 149 13th Street, Charlestown, MA 

    • Resilient Together A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
      Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu
    • Additional information https://rally.partners.org/study/resilienttogether
      Location: 149 13th Street, Charlestown, MA

    Affiliated research partner studies contact:

     McLean Hospital
    Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

    Northeastern University Music-Based Intervention Research Study 
    MBI Flyer
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com

    Beth Israel Deaconess Medical Center

    GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu