Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
Additional Information: www.aptwebstudy.org

WALLe: This study searches for individuals between 60-85 years. In our study, we examine the effect of a non-invasive electrical brain stimulation method called RAVANS on memory.
Contact: wallestudy@mgh.harvard.edu
Additional Information: https://rally.massgeneralbrigham.org/study/walle_study

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos: The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.massgeneralbrigham.org/study/memory_stress
Location: MGH Multicultural Alzheimer’s Prevention Program

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

MOMENT Study: This observational study aims to determine whether the presence of late-onset depressive symptoms in older adults may predict problems in memory and thinking and accumulation of Alzheimer’s Disease-related brain changes.
Contact: Alexa Coussoule 617- 726-3086, mghmomentstudy@partners.org
Additional information: https://rally.massgeneralbrigham.org/study/moment

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: amazan@mgh.harvard.edu
Additional Information: Spanish Memory Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos: The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns.
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Additional information:    Stress Study_Spanish Flyer                                                                                                          Location: MGH Multicultural Alzheimer’s Prevention Program

Boston Latino Aging Study (BLAST): A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional Information: BLAST Flyer Spanish
Location: 149 13^th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study Flyer 

NADALS Basket Trial: Seeking those aged 55-90 with Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), OR Mild to Moderate Alzheimer’s Disease (AD) to complete an 8-month study on the FDA approved medication, Baricitinib. This is a once daily oral medication used for the treatment of rheumatoid arthritis, COVID-19 and alopecia, that we are investigating in memory issues to explore what effect Baricitinib has on inflammatory and neurodegenerative biomarkers related to Alzheimer’s Disease. The study is open label (no placebo), requires blood draws, neurocognitive testing, lumbar punctures, physical exams, and a study partner who can attend some visits. Payment is up to $1,100 for all study related activities and reimbursements.
Contact: Trevor Ragas TRAGAS@mgh.harvard.edu, Devanshi Patel dpatel60@mgh.harvard.edu, AND Kelli Devitte-McKee kdevitte-mckee@mgb.org
Additional information: ACTRU_NADALS_Brochure
Location: MGH Navy Yard, 149 13th St, Charlestown, MA 02129

MemPal – Seeking people to test a wearable chat-based device that supports your memory. Your feedback will enable us to improve the device to eventually help you live more independently and safely at home.
Contact: nmaniar@media.mit.edu.
Additional Information: MemPal flyer

MOMENT Study – This observational study aims to determine whether the presence of late-onset depressive symptoms in older adults may predict problems in memory and thinking and accumulation of Alzheimer’s Disease-related brain changes.
Contact: Alexa Coussoule 617- 726-3086, mghmomentstudy@partners.org
Additional information: https://rally.massgeneralbrigham.org/study/moment

The Active Brains Study: This study is comparing two symptom management programs for older adults with memory-related problems and chronic pain.
Contact: rchen24@mgh.harvard.edu or  (617) 726-3582
Additional Information:  https://rally.massgeneralbrigham.org/study/activebrains1

The START Trial: This study aims to determine whether an investigational drug (CT1812), is beneficial to help slow or stop memory loss in people experiencing early stages of Alzheimer’s disease.
Contact: Gladiliz Rivera-Delpin, griveradelpin1@bwh.harvard.edu or Marla Lech, mlech@bwh.harvard.edu
Additional Information:  https://start-study.org/
Location: Brigham & Women’s Hospital 

NADALS Basket Trial: Seeking those aged 55-90 with Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), OR Mild to Moderate Alzheimer’s Disease (AD) to complete an 8-month study on the FDA approved medication, Baricitinib. This is a once daily oral medication used for the treatment of rheumatoid arthritis, COVID-19 and alopecia, that we are investigating in memory issues to explore what effect Baricitinib has on inflammatory and neurodegenerative biomarkers related to Alzheimer’s Disease. The study is open label (no placebo), requires blood draws, neurocognitive testing, lumbar punctures, physical exams, and a study partner who can attend some visits. Payment is up to $1,100 for all study related activities and reimbursements.
Contact: Trevor Ragas TRAGAS@mgh.harvard.edu, Devanshi Patel dpatel60@mgh.harvard.edu, AND Kelli Devitte-McKee kdevitte-mckee@mgb.org
Additional information: ACTRU_NADALS_Brochure
Location: MGH Navy Yard, 149 13th St, Charlestown, MA 02129

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.massgeneralbrigham.org/study/memory_stress
Location: MGH Multicultural Alzheimer’s Prevention Program

Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location:149 13^th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
Contact: Kyle Pellerin (508-320-6870)  kyle.pellerin@mgh.harvard.edu
Additional information multimodal brochure
Location: 149 13^th Street, Charlestown, MA

Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
Contact: pbm@mgh.harvard.edu
Additional Information: https://rally.partners.org/study/trapad_study

Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

GAMMA -The main purpose of this study is to explore the effects and safety of 2-4 weeks of brain stimulation, to see if the stimulation can affect brain activity to decrease the amount of amyloid-beta and tau (proteins that build up in the brain that may contribute to memory problems) in people with MCI and AD.
Contact: Stacey Monsell, smonsell@bidmc.harvard.edu
Additional Information: Study Flyer

Brain Monitoring Study – This study will test and optimize our device for use in older adults with Alzheimer’s disease. The new information collected from our device will help us better understand how the brain changes with the development of Alzheimer’s disease.
Contact: Jian Shi  jshi16@mgh.harvard.edu or (617) 724-9608
Additional Information: https://rally.massgeneralbrigham.org/study/ad_brain_eval

Narrative Study – The Narrative Medicine Intervention program aims to study the usefulness of a personal storytelling intervention for people living with early cognitive impairment and their care partners. The personal story is based on the individual’s health experience from their perspective.
Contact: Kelsey Biddle, kdbiddle@bwh.harvard.edu or 650-504-7806
Additional Information: Narrative Study Flyer  https://rally.massgeneralbrigham.org/study/personal_health_story_bwh

MemPal – Seeking people to test a wearable chat-based device that supports your memory. Your feedback will enable us to improve the device to eventually help you live more independently and safely at home.
Contact: nmaniar@media.mit.edu
Additional Information: MemPal flyer

Neuromodulation of brain function in Alzheimer’s Disease and Related Dementias – The goal of this clinical trial is to learn more about the effects of non-invasive brain stimulation on memory and brain network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).
Contact: Anna Du (617)-643-6348 or andu@mgh.harvard.edu
Location: 149 13thth Street, Charlestown, MA

Circuit-specific neuromodulation for the treatment of apathy in Alzheimer’s Disease – The goal of this study is to better understand and to better treat apathy in Alzheimer’s disease and Mild Cognitive Impairment. Specifically, we will examine whether a form of non-invasive brain stimulation called “Transcranial Magnetic Stimulation” (TMS) can: (1) change connectivity in brain circuits related to apathy, (2) increase the spread of dopamine (a brain chemical thought to be involved in apathy), and (3) change behaviors on tests of apathy. Participation in this study will consist of four in-person visits where you will undergo brief MRI scanning, TMS, and combined MR/PET scanning.
Contact: Anna Du (617)-643-6348 andu@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

The Active Brains Study: This study is comparing two symptom management programs for older adults with memory-related problems and chronic pain.
Contact: rchen24@mgh.harvard.edu or  (617) 726-3582
Additional Information:  https://rally.massgeneralbrigham.org/study/activebrains1

WALLe: This study searches for individuals between 60-85 years. In our study, we examine the effect of a non-invasive electrical brain stimulation method called RAVANS on memory.
Contact: wallestudy@mgh.harvard.edu
Additional Information: https://rally.massgeneralbrigham.org/study/walle_study

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Location: MGH Multicultural Alzheimer’s Prevention Program

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org

Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13^th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

MemPal Study: aims to test the effectiveness of a wearable cognitive assistant device. The device acts as a memory aid to help individuals with cognitive impairment live more independently at home and reduce caregiver burden
Contact: nmaniar@media.mit.edu
Additional Information: Study flyer

The START Trial: This study aims to determine whether an investigational drug (CT1812), is beneficial to help slow or stop memory loss in people experiencing early stages of Alzheimer’s disease.
Contact: Gladiliz Rivera-Delpin, griveradelpin1@bwh.harvard.edu or Marla Lech, mlech@bwh.harvard.edu
Additional Information:  https://start-study.org/
Location: Brigham & Women’s Hospital  

NADALS Basket Trial: Seeking those aged 55-90 with Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), OR Mild to Moderate Alzheimer’s Disease (AD) to complete an 8-month study on the FDA-approved medication, Baricitinib. This is a once daily oral medication used for the treatment of rheumatoid arthritis, COVID-19, and alopecia, that we are investigating in memory issues to explore what effect Baricitinib has on inflammatory and neurodegenerative biomarkers related to Alzheimer’s Disease. The study is open-label (no placebo), requires blood draws, neurocognitive testing, lumbar punctures, physical exams, and a study partner who can attend some visits. Payment is up to $1,100 for all study-related activities and reimbursements.
Contact: Trevor Ragas TRAGAS@mgh.harvard.edu, Devanshi Patel dpatel60@mgh.harvard.edu, AND Kelli Devitte-McKee kdevitte-mckee@mgb.org
Additional information: ACTRU_NADALS_Brochure
Location: MGH Navy Yard, 149 13th St, Charlestown, MA 02129                                      

Memory Awareness AWARE –A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
Contact: Alexa Coussole, acoussoule@bwh.harvard.edu
More information: https://rally.partners.org/study/the_memoryawareness_study
Location: 149 13^th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
Contact: Kyle Pellerin (508-320-6870)  kyle.pellerin@mgh.harvard.edu
Additional information Multimodal brochure
Location: 149 13^th Street, Charlestown, MA

Tau PET Imaging Study A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Sophia Tchir STCHIR@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

Longitudinal Early Onset Disease Study (LEADS)– A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
Contact: Sam Murdock, smurdock2@mgh.harvard.edu
Additional information: LEADS flyer
Location: 149 13^th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

Brain Monitoring Study – This study will test and optimize our device for use in older adults with Alzheimer’s disease. The new information collected from our device will help us better understand how the brain changes with the development of Alzheimer’s disease.
Contact: Jian Shi  jshi16@mgh.harvard.edu or (617) 724-9608
Additional Information: https://rally.massgeneralbrigham.org/study/ad_brain_eval

Narrative Study – The Narrative Medicine Intervention program aims to study the usefulness of a personal storytelling intervention for people living with early cognitive impairment and their care partners. The personal story is based on the individual’s health experience from their perspective.
Contact: Kelsey Biddle, kdbiddle@bwh.harvard.edu or 650-504-7806
Additional Information: Narrative Study Flyer https://rally.massgeneralbrigham.org/study/personal_health_story_bwh

Neuromodulation of brain function in Alzheimer’s Disease and Related Dementias – The goal of this clinical trial is to learn more about the effects of non-invasive brain stimulation on memory and brain network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).
Contact: Anna Du (617)-643-6348 or andu@mgh.harvard.edu
Location: 149 13thth Street, Charlestown, MA

GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.   
Contact: Julianne Reilly, jrreilly@mgh.harvard.edu
Additional information: https://rally.massgeneralbrigham.org/study/gifted

LRTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      
Contact: Gent Celaj, GCELAJ@mgh.harvard.edu

Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Sophia Tchir STCHIR@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA 

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact:Sophia Tchir  STCHIR@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA 

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
Contact: Gent Celaj GCELAJ@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease.
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13^th Street, Charlestown, MA

Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease.
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13^th Street, Charlestown, MA

Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA).
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13^th Street, Charlestown, MA

• Vascular Pathology in Early and Asymptomatic Cerebral Angiopathy –This study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
  Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu
  Additional information: https://rally.partners.org/study/caamemorystudy
  Location: Mass General Hospital

• Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
  Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
  Additional Information: BLAST Flyer Spanish
  Location: 149 13^th Street, Charlestown, MA

• Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
  Contact: MemoryAndAging@mgh.harvard.edu                                                                  Additional Information: MAC Study flyers 
• ‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
  Contact: amazan@mgh.harvard.edu
  Additional Information: Spanish Memory Study
• The Pocket MRI Study – This study is seeking people with memory complaints and/or Alzheimer’s Disease to help test and improve the performance of a portable,                                                 low magnetic field MRI scanner.
  Contact: Jennifer Guo, 617-643-9681 or jguo22@mgh.harvard.edu
  Additional Information: POCKET-MRI_Outpatient_Flyer

STRIDE Study – The purpose of the study is to explore how mobile health applications impact stress levels in dementia caregivers.
Contact:  MGHSTRIDEstudy@partners.org
Additional Information: STRIDE Flyer

Northeastern University Music-Based Intervention Research Study
MBI Flyer 
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com 

McLean Hospital
Contact: geripsych@partners.org

Beth Israel Deaconess Medical Center:
GAMMA -The main purpose of this study is to explore the effects and safety of 2-4 weeks of brain stimulation, to see if the stimulation can affect brain activity to decrease the amount of amyloid-beta and tau (proteins that build up in the brain that may contribute to memory problems) in people with MCI and AD.
Contact: Stacey Monsell, smonsell@bidmc.harvard.edu

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
Additional Information: www.aptwebstudy.org

NADALS Basket Trial: Seeking those aged 55-90 with Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), OR Mild to Moderate Alzheimer’s Disease (AD) to complete an 8-month study on the FDA approved medication, Baricitinib. This is a once daily oral medication used for the treatment of rheumatoid arthritis, COVID-19 and alopecia, that we are investigating in memory issues to explore what effect Baricitinib has on inflammatory and neurodegenerative biomarkers related to Alzheimer’s Disease. The study is open label (no placebo), requires blood draws, neurocognitive testing, lumbar punctures, physical exams, and a study partner who can attend some visits. Payment is up to $1,100 for all study related activities and reimbursements.
Contact: Trevor RagasTRAGAS@mgh.harvard.edu, Devanshi Patel dpatel60@mgh.harvard.edu, AND Kelli Devitte-McKeekdevitte-mckee@mgb.org
Additional information:ACTRU_NADALS_Brochure
Location: MGH Navy Yard, 149 13th St, Charlestown, MA 02129

The Active Brains Study: This study is comparing two symptom management programs for older adults with memory-related problems and chronic pain.
Contact: rchen24@mgh.harvard.edu or  (617) 726-3582
Additional Information:  https://rally.massgeneralbrigham.org/study/activebrains1

The START Trial: This study aims to determine whether an investigational drug (CT1812), is beneficial to help slow or stop memory loss in people experiencing early stages of Alzheimer’s disease.
Contact: Gladiliz Rivera-Delpin, griveradelpin1@bwh.harvard.edu or Marla Lech, mlech@bwh.harvard.edu
Additional Information:  https://start-study.org/
Location: Brigham & Women’s Hospital 

Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
Contact: pbm@mgh.harvard.edu
Additional Information: https://rally.partners.org/study/trapad_study 

NADALS Basket Trial: Seeking those aged 55-90 with Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), OR Mild to Moderate Alzheimer’s Disease (AD) to complete an 8-month study on the FDA approved medication, Baricitinib. This is a once daily oral medication used for the treatment of rheumatoid arthritis, COVID-19 and alopecia, that we are investigating in memory issues to explore what effect Baricitinib has on inflammatory and neurodegenerative biomarkers related to Alzheimer’s Disease. The study is open label (no placebo), requires blood draws, neurocognitive testing, lumbar punctures, physical exams, and a study partner who can attend some visits. Payment is up to $1,100 for all study related activities and reimbursements.
Contact: Trevor RagasTRAGAS@mgh.harvard.edu, Devanshi Patel dpatel60@mgh.harvard.edu, AND Kelli Devitte-McKeekdevitte-mckee@mgb.org
Additional information:ACTRU_NADALS_Brochure
Location: MGH Navy Yard, 149 13th St, Charlestown, MA 02129

GAMMA -The main purpose of this study is to explore the effects and safety of 2-4 weeks of brain stimulation, to see if the stimulation can affect brain activity to decrease the amount of amyloid-beta and tau (proteins that build up in the brain that may contribute to memory problems) in people with MCI and AD.
Contact: Stacey Monsell, smonsell@bidmc.harvard.edu
Additional Information: Study Flyer

Neuromodulation of brain function in Alzheimer’s Disease and Related Dementias – The goal of this clinical trial is to learn more about the effects of non-invasive brain stimulation on memory and brain network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).
Contact: Anna Du (617)-643-6348 or andu@mgh.harvard.edu
Location: 149 13thth Street, Charlestown, MA

Circuit-specific neuromodulation for the treatment of apathy in Alzheimer’s Disease – The goal of this study is to better understand and to better treat apathy in Alzheimer’s disease and Mild Cognitive Impairment. Specifically, we will examine whether a form of non-invasive brain stimulation called “Transcranial Magnetic Stimulation” (TMS) can: (1) change connectivity in brain circuits related to apathy, (2) increase the spread of dopamine (a brain chemical thought to be involved in apathy), and (3) change behaviors on tests of apathy. Participation in this study will consist of four in-person visits where you will undergo brief MRI scanning, TMS, and combined MR/PET scanning.
Contact: Anna Du (617)-643-6348 andu@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

The Active Brains Study: This study is comparing two symptom management programs for older adults with memory-related problems and chronic pain.
Contact: rchen24@mgh.harvard.edu or  (617) 726-3582
Additional Information:  https://rally.massgeneralbrigham.org/study/activebrains1

BCG vaccine -BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.                                                      Contact: Kate Cropp, kdevitte-mckee@mgb.org 617-643-4802
Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad
Location: 149 13th Street, Charlestown, MA   

Neuromodulation of brain function in Alzheimer’s Disease and Related Dementias – The goal of this clinical trial is to learn more about the effects of non-invasive brain stimulation on memory and brain network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).
Contact: Anna Du (617)-643-6348 or andu@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Circuit-specific neuromodulation for the treatment of apathy in Alzheimer’s Disease – The goal of this study is to better understand and to better treat apathy in Alzheimer’s disease and Mild Cognitive Impairment. Specifically, we will examine whether a form of non-invasive brain stimulation called “Transcranial Magnetic Stimulation” (TMS) can: (1) change connectivity in brain circuits related to apathy, (2) increase the spread of dopamine (a brain chemical thought to be involved in apathy), and (3) change behaviors on tests of apathy. Participation in this study will consist of four in-person visits where you will undergo brief MRI scanning, TMS, and combined MR/PET scanning.
Contact: Anna Du (617)-643-6348 andu@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

The Pocket MRI Study – This study is seeking people with memory complaints and/or Alzheimer’s Disease to help test and improve the performance of a portable,                                                 low magnetic field MRI scanner.
Contact: Jennifer Guo, 617-643-9681 or jguo22@mgh.harvard.edu
Additional Information: POCKET-MRI_Outpatient_Flyer

GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.                      
Contact: Hannah Bedrosian HBEDROSIAN@mgh.harvard.edu

Transcranial Magnetic Stimulation Study -This study evaluates use of repetitive transcranial magnetic stimulation to target areas of memory and language in patients with amnestic mild cognitive impairment and the logogenic or non-fluent variant of primary progressive aphasia.
Contact: Gent Celaj GCELAJ@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

Northeastern University Music-Based Intervention Research Study
MBI Flyer 
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com

McLean Hospital
Contact: Stefanie Wong SWONG18@PARTNERS.ORG

Beth Israel Deaconess Medical Center

GAMMA -The main purpose of this study is to explore the effects and safety of 2-4 weeks of brain stimulation, to see if the stimulation can affect brain activity to decrease the amount of amyloid-beta and tau (proteins that build up in the brain that may contribute to memory problems) in people with MCI and AD.

Contact: Stacey Monsell, smonsell@bidmc.harvard.edu

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory  Study  Flyer

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
Additional Information:  www.aptwebstudy.org

Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13^th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study–   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13^th Street, Charlestown, MA 

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu.
Additional Information: MAC Study flyers                                                                                      

Sleep on Neural Networks in Brain Aging (SONNET) – A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13^th Street, Charlestown, MA

MemPal Study: aims to test the effectiveness of a wearable cognitive assistant device. The device acts as a memory aid to help individuals with cognitive impairment live more independently at home and reduce caregiver burden
Contact: nmaniar@media.mit.edu
Additional Information: Study flyer

MOMENT Study – This observational study aims to determine whether the presence of late-onset depressive symptoms in older adults may predict problems in memory and thinking and accumulation of Alzheimer’s Disease-related brain changes.
Contact: Alexa Coussoule 617- 726-3086, mghmomentstudy@partners.org
Additional information: https://rally.massgeneralbrigham.org/study/moment

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: amazan@mgh.harvard.edu
Additional Information: Spanish Memory & Aging Study

Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional Information: BLAST Flyer Spanish
Location: 149 13^th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study  Flyer

MemPal – Seeking people to test a wearable chat-based device that supports your memory. Your feedback will enable us to improve the device to eventually help you live more independently and safely at home.
Contact: nmaniar@media.mit.edu.
Additional Information: MemPal flyer

MOMENT Study – This observational study aims to determine whether the presence of late-onset depressive symptoms in older adults may predict problems in memory and thinking and accumulation of Alzheimer’s Disease-related brain changes.
Contact: Alexa Coussoule 617- 726-3086, mghmomentstudy@partners.org
Additional information: https://rally.massgeneralbrigham.org/study/moment

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study  Flyer

Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13^th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
Contact: Kyle Pellerin(508-320-6870)    kyle.pellerin@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study–   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/risk_of_alzheimers
Location: 149 13^th Street, Charlestown, MA     

Narrative Study – The Narrative Medicine Intervention program aims to study the usefulness of a personal storytelling intervention for people living with early cognitive impairment and their care partners. The personal story is based on the individual’s health experience from their perspective.
Contact: Kelsey Biddle, kdbiddle@bwh.harvard.edu  or 650-504-7806
Additional Information: Narrative Study Flyer  https://rally.massgeneralbrigham.org/study/personal_health_story_bwh 

MemPal – Seeking people to test a wearable chat-based device that supports your memory. Your feedback will enable us to improve the device to eventually help you live more independently and safely at home.
Contact: nmaniar@media.mit.edu.
Additional Information: MemPal flyer

Memory Awareness – A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
Contact: Alexa Coussole, acoussoule@bwh.harvard.edu
Additional info: https://rally.partners.org/study/the_memoryawareness_study.
Location: 149 13^th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
Contact: Kyle Pellerin (508-320-6870 )  kyle.pellerin@mgh.harvard.edu
Additional information: Multimodal flyer
Location: 149 13^th Street, Charlestown, MA

Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Sophia Tchir  STCHIR@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

Longitudinal Early Onset Disease Study (LEADS)– A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
Contact: Sam Murdock, smurdock2@mgh.harvard.edu
Additional information: AA_LEADS-Brochure_
Location: 149 13^th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study–   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13^th Street, Charlestown, MA 

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

Narrative Study – The Narrative Medicine Intervention program aims to study the usefulness of a personal storytelling intervention for people living with early cognitive impairment and their care partners. The personal story is based on the individual’s health experience from their perspective.
Contact: Kelsey Biddle, kdbiddle@bwh.harvard.edu  or 650-504-7806
Additional Information: Narrative Study Flyer  https://rally.massgeneralbrigham.org/study/personal_health_story_bwh

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)– A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
Contact:  Gent Celaj, GCELAJ@mgh.harvard.edu

Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Sophia Tchir STCHIR@mgh.harvard.edu
Location: 149 13^th Street, Charlestown, MA

Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease.
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13^th Street, Charlestown, MA

Vascular Pathology in Early and Asymptomatic Cerebral Angiopathy –This study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu
Additional information: https://rally.partners.org/study/caamemorystudy
Location: Mass General Hospital

STRIDE Study – The purpose of the study is to explore how mobile health applications impact stress levels in dementia caregivers.
Contact:  MGHSTRIDEstudy@partners.org
Additional Information: STRIDE Flyer

Mobile App-Based Lessons on Caregiving or Guided Imagery Study – This study aims to improve the mood and energy of caregivers, as well as provide lessons in caregiving.
Contact: English:  CAREGIVERS@MGB.ORG, Spanish: Miranda Zea cuidadores@mgb.org
Additional Information: Caregiver Study Flyer.   Caregiver Flyer Spanish.

SOCIAL Study – This study seeks caregivers to participate in (6) weekly, 60-minute training sessions teaching caregivers skills around mindfulness, self-compassion, and navigating their care recipient’s challenging behaviors.
Contact: socialstudymgh@mgb.org  or 617-726-9623
Additional Information: SOCIAL Study Flyer   or visit https://rally.massgeneralbrigham.org/study/socialstudymgh

 McLean Hospital
Contact: geripsych@partners.org

Northeastern University Music-Based Intervention Research Study 
MBI Flyer
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com

Beth Israel Deaconess Medical Center
GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.