Join a Study

When designing a study, researchers give a lot of thought to who should participate. Research teams really want a mix of people from different races, genders, ethnicities, ages, locations, and identities. This mix is very important to make sure that what they are testing works well for everyone. Since each study wants to include lots of different types of people, sometimes they might have to stop asking one group to join so they can have more people from another group.

If you have questions or want more information, call us at (617) 278-0600.

To learn more about different types of diagnoses click here.

Guide to Clinical Trials & Observational Studies

➡ Prevention

Prevention

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

➡ Cognitively Normal (Studies for people with no symptoms of memory loss or dementia)

Normal Cognition

WALLe: This study searches for individuals between 60-85 years. In our study, we examine the effect of a non-invasive electrical brain stimulation method called RAVANS on memory.
Contact: wallestudy@mgh.harvard.edu
Additional Information: https://rally.massgeneralbrigham.org/study/walle_study

BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 minutes visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.
Contact: Shadia Farah, sfarah5@mgh.harvard.edu 

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.massgeneralbrigham.org/study/memory_stress
Location: MGH Multicultural Alzheimer’s Prevention Program

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA

MOMENT StudyThis observational study aims to determine whether the presence of late-onset depressive symptoms in older adults may predict problems in memory and thinking and accumulation of Alzheimer’s Disease-related brain changes.
Contact: Alexa Coussoule 617- 726-3086, mghmomentstudy@partners.org
Additional information: https://rally.massgeneralbrigham.org/study/moment

Normal Cognition Spanish Speaker

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: amazan@mgh.harvard.edu
Additional Information: Spanish Memory Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns.
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Additional information:    Stress Study_Spanish Flyer                                                                                                          Location: MGH Multicultural Alzheimer’s Prevention Program

Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional Information: BLAST Flyer Spanish
Location: 149 13th Street, Charlestown, MA

Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.partners.org/study/_latino_habs
Location: 149 13th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

 

Sort by Diagnosis

You may be eligible if you have:

Subjective Cognitive Decline

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study Flyer 

Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.
Contact: Alexa Coussole (617) 726-3086
Additional information: https://rally.partners.org/study/study_scd.
Click here for study flyer.
Location: 149 13th Street, Charlestown, MA

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or
Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA

MemPalSeeking people to test a wearable chat-based device that supports your memory. Your feedback will enable us to improve the device to eventually help you live more independently and safely at home.
Contact: nmaniar@media.mit.edu.
Additional Information: MemPal flyer

MOMENT StudyThis observational study aims to determine whether the presence of late-onset depressive symptoms in older adults may predict problems in memory and thinking and accumulation of Alzheimer’s Disease-related brain changes.
Contact: Alexa Coussoule 617- 726-3086, mghmomentstudy@partners.org
Additional information: https://rally.massgeneralbrigham.org/study/moment

 

Mild Cognitive Impairment

BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 minutes visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.
Contact: Shadia Farah, sfarah5@mgh.harvard.edu 

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.massgeneralbrigham.org/study/memory_stress
Location: MGH Multicultural Alzheimer’s Prevention Program

Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location:149 13th Street, Charlestown, MA

Sleep on Neural Networks in Brain Aging (SONNET) – A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu  or
Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s diseaseA study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
Contact: Kyle Pellerin (508-320-6870)  kyle.pellerin@mgh.harvard.edu
Additional information multimodal brochure
Location: 149 13th Street, Charlestown, MA

Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
Contact: pbm@mgh.harvard.edu
Additional Information: https://rally.partners.org/study/trapad_study

Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

GAMMA -The main purpose of this study is to explore the effects and safety of 2-4 weeks of brain stimulation, to see if the stimulation can affect brain activity to decrease the amount of amyloid-beta and tau (proteins that build up in the brain that may contribute to memory problems) in people with MCI and AD.
Contact: Stacey Monsell, smonsell@bidmc.harvard.edu
Additional Information: Study Flyer

Lightwave – Sage TherapeuticsThis 20 week, double-blind study, will look at the effects of SAGE-718 on memory and cognition via NMDAR modulation. We are looking for Individuals between the ages of 50-80 who have been previously diagnosed with MCI and/or Mild Dementia due to Alzheimer’s and who are not taking Namenda/Memantine to participate.
Contact: kdevitte-mckee@mgb.org  or 617-643-7945

Brain Monitoring Study – This study will test and optimize our device for use in older adults with Alzheimer’s disease. The new information collected from our device will help us better understand how the brain changes with the development of Alzheimer’s disease.
Contact: Jian Shi  jshi16@mgh.harvard.edu or (617) 724-9608
Additional Information: https://rally.massgeneralbrigham.org/study/ad_brain_eval

CELIA Study – The CELIA clinical trial is researching a potential treatment for people with mild cognitive impairment due to Alzheimer’s disease or mild Alzheimer’s disease dementia by focusing on a protein called tau We want to understand if different doses of a study drug called BIIB080 could be safe and have an effect on the progression of Alzheimer’s disease.
Contact:
hhustead@bwh.harvard.edu
Additional Information: CELIA study brochure

Narrative Study – The Narrative Medicine Intervention program aims to study the usefulness of a personal storytelling intervention for people living with early cognitive impairment and their care partners. The personal story is based on the individual’s health experience from their perspective.
Contact: Kelsey Biddle, kdbiddle@bwh.harvard.edu or 650-504-7806
Additional Information: Narrative Study Flyer  https://rally.massgeneralbrigham.org/study/personal_health_story_bwh

MemPal – Seeking people to test a wearable chat-based device that supports your memory. Your feedback will enable us to improve the device to eventually help you live more independently and safely at home.
Contact: nmaniar@media.mit.edu
Additional Information: MemPal flyer

Neuromodulation of brain function in Alzheimer’s Disease and Related Dementias – The goal of this clinical trial is to learn more about the effects of non-invasive brain stimulation on memory and brain network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).
Contact: Anna Du (617)-643-6348 or andu@mgh.harvard.edu
Location: 149 13thth Street, Charlestown, MA

 

 

Normal Cognition

WALLe: This study searches for individuals between 60-85 years. In our study, we examine the effect of a non-invasive electrical brain stimulation method called RAVANS on memory.
Contact: wallestudy@mgh.harvard.edu
Additional Information: https://rally.massgeneralbrigham.org/study/walle_study

BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 minutes visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.
Contact: Shadia Farah, sfarah5@mgh.harvard.edu 

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study Flyer

Chronic Stress as a Risk Factor for Age-Related Cognitive Decline in Latinos The overall goal of this study is to assess the impact of chronic stress, measured via paper-pencil questionnaires and a hair sample, on memory and thinking in Latino and Non-Latino adults with and without cognitive concerns
Contact: Alex Badillo-Cabrera, abadillocabrera@mgh.harvard.edu
Location: MGH Multicultural Alzheimer’s Prevention Program

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org

Instrumental Activities of Daily Living (IADL) A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA

MemPal Study: aims to test the effectiveness of a wearable cognitive assistant device. The device acts as a memory aid to help individuals with cognitive impairment live more independently at home and reduce caregiver burden
Contact: nmaniar@media.mit.edu
Additional Information: Study flyer

Alzheimer's Disease

NMN AD Study– Men and women aged 55-85 who are diagnosed with mild Alzheimer’s disease are invited to join our study which is investigating whether study drug MIB-626 can  be beneficial for Alzheimer’s patients.
Contact: MLECH@BWH.HARVARD.EDU
Additional Information: NMN AD Study Flyer
Location: 60 Fenwood Road Boston, MA 02115                                             

Memory Awareness AWAREA study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
Contact: Alexa Coussole, acoussoule@bwh.harvard.edu
More information: https://rally.partners.org/study/the_memoryawareness_study
Location: 149 13th Street, Charlestown, MA

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu
Additional information:  https://rally.partners.org/study/sonnet
Location: 149 13th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
Contact:
Kyle Pellerin (508-320-6870)  kyle.pellerin@mgh.harvard.edu
Additional information Multimodal brochure
Location: 149 13th Street, Charlestown, MA

Tau PET Imaging Study A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Sophia Tchir STCHIR@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Longitudinal Early Onset Disease Study (LEADS) A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
Contact: Sam Murdock, smurdock2@mgh.harvard.edu
Additional information: LEADS flyer
Location: 149 13th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

Lightwave – Sage TherapeuticsThis 20 week, double-blind study, will look at the effects of SAGE-718 on memory and cognition via NMDAR modulation. We are looking for Individuals between the ages of 50-80 who have been previously diagnosed with MCI and/or Mild Dementia due to Alzheimer’s and who are not taking Namenda/Memantine to participate.
Contact: kdevitte-mckee@mgb.org  or 617-643-7945

Brain Monitoring Study – This study will test and optimize our device for use in older adults with Alzheimer’s disease. The new information collected from our device will help us better understand how the brain changes with the development of Alzheimer’s disease.
Contact: Jian Shi  jshi16@mgh.harvard.edu or (617) 724-9608
Additional Information: https://rally.massgeneralbrigham.org/study/ad_brain_eval

CELIA Study – The CELIA clinical trial is researching a potential treatment for people with mild cognitive impairment due to Alzheimer’s disease or mild Alzheimer’s disease dementia by focusing on a protein called tau We want to understand if different doses of a study drug called BIIB080 could be safe and have an effect on the progression of Alzheimer’s disease.
Contact: hhustead@bwh.harvard.edu
Additional Information: CELIA study brochure

Narrative Study – The Narrative Medicine Intervention program aims to study the usefulness of a personal storytelling intervention for people living with early cognitive impairment and their care partners. The personal story is based on the individual’s health experience from their perspective.
Contact: Kelsey Biddle, kdbiddle@bwh.harvard.edu or 650-504-7806
Additional Information: Narrative Study Flyer https://rally.massgeneralbrigham.org/study/personal_health_story_bwh

Neuromodulation of brain function in Alzheimer’s Disease and Related Dementias – The goal of this clinical trial is to learn more about the effects of non-invasive brain stimulation on memory and brain network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).
Contact: Anna Du (617)-643-6348 or andu@mgh.harvard.edu
Location: 149 13thth Street, Charlestown, MA

 

 

➡ Frontotemporal Dementia

Frontotemporal Dementia

GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.   
Contact: Julianne Reilly, jrreilly@mgh.harvard.edu
Additional information: https://rally.massgeneralbrigham.org/study/gifted

LRTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      
Contact: Gent Celaj, GCELAJ@mgh.harvard.edu

 

Primary Progressive Aphasia

Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Sophia Tchir STCHIR@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA 

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Posterior Cortical Atrophy

Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact:Sophia Tchir  STCHIR@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA 

Progressive Supranuclear Palsy

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Cortical Basal Syndrome

 

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      
Contact: Erin Krahn, ekrahn@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
Contact: Gent Celaj GCELAJ@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Lewy Body Dementia

Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease.
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA

Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA).
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA

Parkinson Disease Dementia

Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease.
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA

Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA).
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA

Vascular Dementia

  • Vascular Pathology in Early and Asymptomatic Cerebral AngiopathyThis study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
    Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/caamemorystudy
    Location: Mass General Hospital

➡ Additional Studies

Spanish Speaker

  • Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
    Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
    Additional InformationBLAST Flyer Spanish
    Location: 149 13th Street, Charlestown, MA
  •  
  • Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
    Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/_latino_habs
    Location: 149 13th Street, Charlestown, MA
  • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    Contact: MemoryAndAging@mgh.harvard.edu                                                                 
    Additional Information: MAC Study flyers

  • ‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
    Contact: amazan@mgh.harvard.edu
    Additional Information: Spanish Memory Study

   

Caregiver

 

STRIDE StudyThe purpose of the study is to explore how mobile health applications impact stress levels in dementia caregivers.
Contact:  MGHSTRIDEstudy@partners.org
Additional Information: STRIDE Flyer

 

Mobile App-Based Lessons on Caregiving or Guided Imagery StudyThis study aims to improve the mood and energy of caregivers, as well as provide lessons in caregiving.

Contact: English: Paulina Gutierrez  at  CAREGIVERS@MGB.ORG, Spanish: Miranda Zea cuidadores@mgb.org
Additional Information: Caregiver Study Flyer English.   Caregiver Study Flyer Spanish.

 

SOCIAL Study – This study seeks caregivers to participate in (6) weekly, 60-minute training sessions teaching caregivers skills around mindfulness, self-compassion, and navigating their care recipient’s challenging behaviors.
Contact: Aniyah Travis at atravis1@mgh.harvard.edu or 617-726-9623
Additional Information: SOCIAL Study Flyer –

Affiliate Research Studies Contact:

Northeastern University Music-Based Intervention Research Study
MBI Flyer 
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com 

McLean Hospital
Contact: geripsych@partners.org

Beth Israel Deaconess Medical Center:
GAMMA -The main purpose of this study is to explore the effects and safety of 2-4 weeks of brain stimulation, to see if the stimulation can affect brain activity to decrease the amount of amyloid-beta and tau (proteins that build up in the brain that may contribute to memory problems) in people with MCI and AD.
Contact: Stacey Monsell, smonsell@bidmc.harvard.edu

Sort by Study Type

➡ A Drug or Intervention Trial

Prevention of Alzheimer’s Disease in Normal Adults

 

AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.
Contact: 617-278-0600
Additional information: : https://www.aheadstudy.org
Location:  60 Fenwood Road, Boston, MA

Older Adults Concerned About Their Memory (Subjective Cognitive Decline)

Check back soon!

Patients with Mild Cognitive Impairment

 

Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85
Contact: pbm@mgh.harvard.edu
Additional Information: https://rally.partners.org/study/trapad_study 

GAMMA -The main purpose of this study is to explore the effects and safety of 2-4 weeks of brain stimulation, to see if the stimulation can affect brain activity to decrease the amount of amyloid-beta and tau (proteins that build up in the brain that may contribute to memory problems) in people with MCI and AD.
Contact: Stacey Monsell, smonsell@bidmc.harvard.edu
Additional Information: Study Flyer

CELIA Study – The CELIA clinical trial is researching a potential treatment for people with mild cognitive impairment due to Alzheimer’s disease or mild Alzheimer’s disease dementia by focusing on a protein called tau We want to understand if different doses of a study drug called BIIB080 could be safe and have an effect on the progression of Alzheimer’s disease. 
Contact:
hhustead@bwh.harvard.edu
Additional Information: CELIA study brochure

Neuromodulation of brain function in Alzheimer’s Disease and Related Dementias – The goal of this clinical trial is to learn more about the effects of non-invasive brain stimulation on memory and brain network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).
Contact: Anna Du (617)-643-6348 or andu@mgh.harvard.edu
Location: 149 13thth Street, Charlestown, MA

 

Patients with Alzheimer’s Disease Dementia

NMN AD Study – Men and women aged 55-85 who are diagnosed with mild Alzheimer’s disease are invited to join our study which is investigating whether study drug MIB-626 can  be beneficial for Alzheimer’s patients.
Contact: MLECH@BWH.HARVARD.EDU
Additional Information: NMN AD Study Flyer
Location: 60 Fenwood Road Boston, MA 02115

BCG vaccine -BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.                                                      Contact: Kate Cropp, kdevitte-mckee@mgb.org 617-643-4802
Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad
Location: 149 13th Street, Charlestown, MA   

CELIA Study – The CELIA clinical trial is researching a potential treatment for people with mild cognitive impairment due to Alzheimer’s disease or mild Alzheimer’s disease dementia by focusing on a protein called tau We want to understand if different doses of a study drug called BIIB080 could be safe and have an effect on the progression of Alzheimer’s disease. 
Contact:
hhustead@bwh.harvard.edu
Additional Information: CELIA study brochure

Neuromodulation of brain function in Alzheimer’s Disease and Related Dementias – The goal of this clinical trial is to learn more about the effects of non-invasive brain stimulation on memory and brain network function in cognitively unimpaired older adults and in patients with amnestic mild cognitive impairment (aMCI). This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls memory. Changes resulting from this stimulation will be measured with behavioral tests of memory and general cognition, as well as by taking images of your brain with Magnetic Resonance Imaging (MRI).
Contact: Anna Du (617)-643-6348 or andu@mgh.harvard.edu
Location: 149 13thth Street, Charlestown, MA

 

Patients with Frontotemporal Dementia or Primary Progressive Aphasia

GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.                      
Contact: Hannah Bedrosian HBEDROSIAN@mgh.harvard.edu

Transcranial Magnetic Stimulation Study -This study evaluates use of repetitive transcranial magnetic stimulation to target areas of memory and language in patients with amnestic mild cognitive impairment and the logogenic or non-fluent variant of primary progressive aphasia.
Contact: Gent Celaj GCELAJ@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Affiliate Research Studies Contact:

Northeastern University Music-Based Intervention Research Study
MBI Flyer 
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com

 

McLean Hospital
Contact: Stefanie Wong SWONG18@PARTNERS.ORG

 

Beth Israel Deaconess Medical Center

GAMMA -The main purpose of this study is to explore the effects and safety of 2-4 weeks of brain stimulation, to see if the stimulation can affect brain activity to decrease the amount of amyloid-beta and tau (proteins that build up in the brain that may contribute to memory problems) in people with MCI and AD.

Contact: Stacey Monsell, smonsell@bidmc.harvard.edu

➡ An Observational Study (no drug or intervention):

If you are Cognitively Normal (no memory loss or dementia):

BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 minutes visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.
Contact: Shadia Farah, sfarah5@mgh.harvard.edu 

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory  Study  Flyer

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
Additional Information:  
www.aptwebstudy.org

Instrumental Activities of Daily Living (IADL) A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13th Street, Charlestown, MA 

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu.
Additional Information: MAC Study flyers
                                                                                      

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA

MemPal Study: aims to test the effectiveness of a wearable cognitive assistant device. The device acts as a memory aid to help individuals with cognitive impairment live more independently at home and reduce caregiver burden
Contact: nmaniar@media.mit.edu
Additional Information: Study flyer

MOMENT StudyThis observational study aims to determine whether the presence of late-onset depressive symptoms in older adults may predict problems in memory and thinking and accumulation of Alzheimer’s Disease-related brain changes.
Contact: Alexa Coussoule 617- 726-3086, mghmomentstudy@partners.org
Additional information: https://rally.massgeneralbrigham.org/study/moment

Cognitively Normal and a Spanish Speaker

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: amazan@mgh.harvard.edu
Additional Information: Spanish Memory & Aging Study

Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional Information: BLAST Flyer Spanish
Location: 149 13th Street, Charlestown, MA

Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
Contact: Alex Badillo Cabrera, abadillocabrera@mgh.harvard.edu
Additional information: https://rally.partners.org/study/_latino_habs
Location: 149 13th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

Older Adults Concerned About Their Memory (Subjective Cognitive Decline)

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study  Flyer

Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.
Contact: Alexa Coussole (617) 726-3086
Additional information: https://rally.partners.org/study/study_scd
Click here for study flyer
Location: 149 13th Street, Charlestown, MA.   

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu  or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA

MemPal – Seeking people to test a wearable chat-based device that supports your memory. Your feedback will enable us to improve the device to eventually help you live more independently and safely at home.
Contact: nmaniar@media.mit.edu.
Additional Information: MemPal flyer

MOMENT StudyThis observational study aims to determine whether the presence of late-onset depressive symptoms in older adults may predict problems in memory and thinking and accumulation of Alzheimer’s Disease-related brain changes.
Contact: Alexa Coussoule 617- 726-3086, mghmomentstudy@partners.org
Additional information: https://rally.massgeneralbrigham.org/study/moment

 

Patients with Mild Cognitive Impairment

 BIONIC: Patients at the MGH Memory Disorders Unit will have the opportunity to complete a 30-45 minutes visit completing questionnaires and a blood draw. They will have the optional to return for longitudinal follow up once a year at the time of their clinic appointment.
Contact: Shadia Farah, sfarah5@mgh.harvard.edu 

‘The Memory Study’ at the Massachusetts Alzheimer’s Disease Research Center: An observational study for participants 50 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.
Contact: JJOHANSON1@mgh.harvard.edu
Additional Information: Memory Study  Flyer

Instrumental Activities of Daily Living (IADL)A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.
Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13th Street, Charlestown, MA

Sleep on Neural Networks in Brain Aging (SONNET)A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet
Location:149 13th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.
Contact: Kyle Pellerin(508-320-6870)    kyle.pellerin@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study  A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/risk_of_alzheimers
Location: 149 13th Street, Charlestown, MA     

Narrative Study – The Narrative Medicine Intervention program aims to study the usefulness of a personal storytelling intervention for people living with early cognitive impairment and their care partners. The personal story is based on the individual’s health experience from their perspective.
Contact: Kelsey Biddle, kdbiddle@bwh.harvard.edu  or 650-504-7806
Additional Information: Narrative Study Flyer  https://rally.massgeneralbrigham.org/study/personal_health_story_bwh 

MemPal – Seeking people to test a wearable chat-based device that supports your memory. Your feedback will enable us to improve the device to eventually help you live more independently and safely at home.
Contact: nmaniar@media.mit.edu.
Additional Information: MemPal flyer

 

Patients with Alzheimer’s Disease Dementia

Memory Awareness – A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
Contact: Alexa Coussole, acoussoule@bwh.harvard.edu
Additional info: https://rally.partners.org/study/the_memoryawareness_study.
Location: 149 13th Street, Charlestown, MA

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
Contact: Valentina Paz Pinilla, VPINILLA@mgh.harvard.edu
Additional information https://rally.partners.org/study/sonnet
Location: 149 13th Street, Charlestown, MA

Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
Contact: Kyle Pellerin (508-320-6870 )  kyle.pellerin@mgh.harvard.edu
Additional information: Multimodal flyer
Location: 149 13th Street, Charlestown, MA

 

Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Sophia Tchir  STCHIR@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Longitudinal Early Onset Disease Study (LEADS) A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
Contact: Sam Murdock, smurdock2@mgh.harvard.edu
Additional information: AA_LEADS-Brochure_
Location: 149 13th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13th Street, Charlestown, MA 

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
Contact: MemoryAndAging@mgh.harvard.edu
Additional Information: MAC Study flyers

Narrative Study – The Narrative Medicine Intervention program aims to study the usefulness of a personal storytelling intervention for people living with early cognitive impairment and their care partners. The personal story is based on the individual’s health experience from their perspective.
Contact: Kelsey Biddle, kdbiddle@bwh.harvard.edu  or 650-504-7806
Additional Information: Narrative Study Flyer  https://rally.massgeneralbrigham.org/study/personal_health_story_bwh

 

Patients with Frontotemporal Dementia, Primary Progressive Aphasia, Posterior Cortical Atrophy, Progressive Supranuclear Palsy or Corticobasal Syndrome

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)– A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
Contact:  Gent Celaj, GCELAJ@mgh.harvard.edu

Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
Contact: Sophia Tchir STCHIR@mgh.harvard.edu
Location: 149 13th Street, Charlestown, MA

Patients with Lewy Body Dementia or Parkinson’s Disease with Dementia

Investigation of Epigenetic Mechanisms in Parkinson’s Disease and dementia with Lewy bodies patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in the brain in dementia with Lewy bodies (DLB) and Parkinson’s disease.
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA

 

Web-Based Automated Imaging Differentiation of Parkinsonism – This study is testing an MRI strategy to improve the diagnosis of Parkinson’s disease, progressive supranuclear palsy (PSP), and multiple systems atrophy (MSA).
Contact: Anna Goodheart agoodheart@partners.org
Location: 149 13th Street, Charlestown, MA

 

Patients with Vascular Disease and Cerebral Amyloid Antipathy

Vascular Pathology in Early and Asymptomatic Cerebral AngiopathyThis study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu
Additional information: https://rally.partners.org/study/caamemorystudy
Location: Mass General Hospital

A Caregiver

STRIDE StudyThe purpose of the study is to explore how mobile health applications impact stress levels in dementia caregivers.
Contact:  MGHSTRIDEstudy@partners.org
Additional Information: STRIDE Flyer

Mobile App-Based Lessons on Caregiving or Guided Imagery Study – This study aims to improve the mood and energy of caregivers, as well as provide lessons in caregiving.
Contact: English: Paulina Gutierrez  at  CAREGIVERS@MGB.ORG, Spanish: Miranda Zea cuidadores@mgb.org
Additional Information: Caregiver Study Flyer.   Caregiver Flyer Spanish.

SOCIAL Study – This study seeks caregivers to participate in (6) weekly, 60-minute training sessions teaching caregivers skills around mindfulness, self-compassion, and navigating their care recipient’s challenging behaviors.
Contact: Aniyah Travis at atravis1@mgh.harvard.edu  or 617-726-9623
Additional Information: SOCIAL Study Flyer

 

 

 

Affiliated research partner studies contact:

 McLean Hospital
Contact: geripsych@partners.org

 

Northeastern University Music-Based Intervention Research Study 
MBI Flyer
https://web.northeastern.edu/mindlab/
Contact: mindlabwes@gmail.com

Beth Israel Deaconess Medical Center
GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

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