Join a Study

The MADRC research  team is dedicated to finding a cure for Alzheimer’s disease and related dementias. 

We offer many cutting-edge studies that are both federally and privately funded. Please see the list of studies seeking research participant volunteers below.

Have questions or need more information?  Call us at 617-278-0600.  We are here to help!

To learn more about different types of diagnoses click here.

Guide to Clinical Trials & Observational Studies

➡ Prevention

Prevention

AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.

Contact: (617) 278-0600.                                                                                                            Additional information: https://www.aheadstudy.org                                                                Location:  60 Fenwood Road, Boston, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

Contact: MemoryAndAging@mgh.harvard.edu                                                            Additional Information: MAC Flyer

➡ Cognitively Normal (Studies for people with no symptoms of memory loss or dementia)

Click to enlarge

Normal Cognition

APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
www.aptwebstudy.org

 

Instrumental Activities of Daily Living (IADL) A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.

Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu                                                            Additional information: https://rally.partners.org/study/study_iadl
Location: 149 13th Street, Charlestown, MA

Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.

Contact: KCROPP1@mgh.harvard.edu
Additional information: https://rally.partners.org/study/lifespan_biobank
Location: 149 13th Street, Charlestown, MA

Alzheimer’s Disease EEG Sleep Study   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.

Contact: purdonlab@mgh.harvard.edu
Additional information: https://rally.partners.org/study/noninvasive_biomarkers
Location: 149 13th Street, Charlestown, MA

Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

Contact: MemoryAndAging@mgh.harvard.edu                                                                          Additional Information: MAC Flyer

Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.

Contact: Danielle Ross,  dross6@mgh.harvard.edu or
Raina Levin, rlevin4@mgh.harvard.edu
Additional information: https://rally.partners.org/study/sonnet                          Location:149 13th Street, Charlestown, MA

    Normal Cognition Spanish Speaker

    Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
    Contact: Jairo Martinez  jmartinez24@mgh.harvard.edu
    Additional Information: BLAST Flyer Spanish
    Location: 149 13th Street, Charlestown, MA

    Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
    Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/_latino_habs
    Location: 149 13th Street, Charlestown, MA

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    Contact: MemoryAndAging@mgh.harvard.edu                                                                    
    Additional Information: MAC Flyer Spanish

     

    Click to enlarge

    Sort by Diagnosis

    You may be eligible if you have:

    Subjective Cognitive Decline

    Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.

    Contact: Zoe Katz,  zskatz@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/study_scd.                      Location: 149 13th Street, Charlestown, MA

     

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.

    Contact: Danielle Ross,  dross6@mgh.harvard.edu or
    Raina Levin, rlevin4@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/sonnet                          Location:149 13th Street, Charlestown, MA

     

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, CSF, and other bodily fluid to gain a better understanding of various neurodegenerative diseases.

    Contact:
    KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/lifespan_biobank
    Location: 149 13th Street, Charlestown, MA

     

    Mild Cognitive Impairment

    Instrumental Activities of Daily Living (IADL) – A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.

    Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu                                                  Additional information: https://rally.partners.org/study/study_iadl
    Location:149 13th Street, Charlestown, MA

    BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information:https://rally.massgeneralbrigham.org/study/bcg_in_ad

    Location: 149 13th Street, Charlestown, MA   

    Sleep on Neural Networks in Brain Aging (SONNET) – A Study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.

    Contact: Danielle Ross,dross6@mgh.harvard.edu or
    Raina Levin,rlevin4@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/sonnet
    Location:149 13th Street, Charlestown, MA

    Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.

    Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
    Additional information multimodal brochure
    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.

    Contact:  KCROPP1@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/lifespan_biobank
    Location: 149 13th Street, Charlestown, MA

    Alzheimer’s Disease EEG Sleep Study–   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).

    Contact: purdonlab@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/risk_of_alzheimers
    Location: 149 13th Street, Charlestown, MA

    Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85

    Contact: pbm@mgh.harvard.edu
    Additional Information:
    https://rally.partners.org/study/trapad_study

    Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

    Contact: MemoryAndAging@mgh.harvard.edu

    Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body.

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu
    Additional Information: https://rally.partners.org/study/novartis
    Location: 149 13th Street, Charlestown, MA

     

    Alzheimer's Disease

    Cyclerion – an investigational medication that penetrates the central nervous system and increases the activity of a molecule pathway that affects neuronal function, controls neuronal inflammation, and vascular function.
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/cyclerion

    Location: 149 13th Street, Charlestown, MA     

    BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination. 

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad

    Location: 149 13th Street, Charlestown, MA    

    Athira – a phase II study of ATH -1017, an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Informationhttps://rally.partners.org/study/ath_1017
    Location: 149 13th Street, Charlestown, MA                                                             

    Memory AwarenessA study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
    Contact: Sharon Wang, swang72@mgh.harvard.edu

    More information: https://rally.partners.org/study/the_memoryawareness_study
    Location: 149 13th Street, Charlestown, MA

    Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
    Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
    Additional information:  https://rally.partners.org/study/sonnet
    Location: 149 13th Street, Charlestown, MA

    Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
    Contact:
    Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
    Additional information Multimodal brochure
    Location: 149 13th Street, Charlestown, MA

    Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
    Contact: Katherine Cropp,  KCROPP1@mgh.harvard.edu 617-643-4802
    Additional information: https://rally.partners.org/study/lifespan_biobank
    Location: 149 13th Street, Charlestown, MA

    Tau PET Imaging Study A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
    Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
    Location: 149 13th Street, Charlestown, MA

    Longitudinal Early Onset Disease Study (LEADS) A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
    Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
    Additional information: LEADS flyer
    Location: 149 13th Street, Charlestown, MA

    Alzheimer’s Disease EEG Sleep Study   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
    Contact: purdonlab@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/noninvasive_biomarkers
    Location: 149 13th Street, Charlestown, MA

    Resilient Together Study A study seeking to understand the experiences, needs, and preferences of individuals with a form of young onset dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
    Contact: Paula Popok 617-724-0051 ppopok@mgh.harvard.edu
    Additional information: https://rally.partners.org/study/resilienttogether
    Location: 149 13th Street, Charlestown, MA

    Dementia, Care Planning and Surgery -This is a study to help understand the effectiveness of advance care planning for participants with dementia and either considering or considered surgery.
    Contact: Stephen Perez: 617-732-6176 sperez14@bwh.harvard.edu
    Additional information: https://rally.partners.org/study/careplanningdementia
    Location:  60 Fenwood Road, Boston, MA

    JNJ Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
    Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.partners.org/study/johnsonandjohnson

    Memory & Aging Cohort Study (MAC) – Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
    Contact: MemoryAndAging@mgh.harvard.edu

    Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.partners.org/study/novartis
    Location: 149 13th Street, Charlestown, MA

    Ornish – A research study designed to see if lifestyle changes may slow down, lessen, or potentially reverse the progression of Alzheimer’s disease. Participants in this study will make changes to their diet, and participate in daily exercise, stress management, and group support.Contact: Joe Wood, JWOOD20@mgh.harvard.edu 617-724-9993Additional Information https://rally.partners.org/study/lifestyleintervention  Location: 149 13th Street, Charlestown, MA    

    NMN – Men and women aged 55-85 who are diagnosed with mild Alzheimer’s Disease are invited to join our study which is investigating if an oral dietary supplement can be beneficial for Alzheimer’s patients.Contact: Bella Levesque, ilevesque@bwh.harvard.eduAdditional Information:https://rally.massgeneralbrigham.org/study/adsupplement Location: 60 Fenwood Road Boston, MA 02115

     

    Click to enlarge

    ➡ Frontotemporal Dementia

    Frontotemporal Dementia

    • RTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.                      

      Contact: Erin Krahn, ekrahn@mgh.harvard.edu

    GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.                      

    Contact: Megan Hoffman mahoffma@bidmc.harvard.edu

     

    Primary Progressive Aphasia

    • Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu

         Location: 149 13th Street, Charlestown, MA 

    • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, a family member with medical history of FTD.
      Contact: Erin Krahn, ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Posterior Cortical Atrophy

    • Tau PET Imaging Study -A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Progressive Supranuclear Palsy

    • 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA 

     

    • AARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
      Contact: Erin Krahn, ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Cortical Basal Syndrome

    • 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

       

    • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
      Contact: Erin Krahn, ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Lewy Body Dementia

    • Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease.
      Contact: Molly Quan mquan4@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

       

    • Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
      Contact: Molly Quan mquan4@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Parkinson Disease Dementia

    • Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease.
      Contact: Molly Quan mquan4@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA
    •  
    • Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
      Contact: Molly Quan mquan4@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Vascular Dementia

    • Vascular Pathology in Early and Asymptomatic Cerebral AngiopathyThis study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
      Contact: Vanessa Gonzlaez vagonzalez@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/caamemorystudy
      Location: Mass General Hospital

    ➡ Additional Studies

    Spanish Speaker

    • Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
      Contact: Jairo Martinez  jmartinez24@mgh.harvard.edu
      Additional InformationBLAST Flyer Spanish
      Location: 149 13th Street, Charlestown, MA
    •  
    • Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
      Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/_latino_habs
      Location: 149 13th Street, Charlestown, MA

    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
      Contact: MemoryAndAging@mgh.harvard.edu                                                                    
      Additional Information: MAC Flyer Spanish

    • MADRC Memory & Aging Study: An observational study for participants 65 years old and over with or without memory loss/dementia. The study consists of a yearly visit with a doctor to complete memory testing. The goal is to gather long-term data to help better understand the aging brain.                                                                                   Contactrobregongarcia@mgh.harvard.edu                                                                    Additional Information: Spanish Memory & Aging Study

       

    Caregiver

    • Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
      Contact Erin Krahn: ekrahn@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA
    •  
    • Resilient Together A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
      Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu
      Additional information https://rally.partners.org/study/resilienttogether
      Location: 149 13th Street, Charlestown, MA

    Affiliate Research Studies Contact:

     Northeastern University Music-Based Intervention Research Study
    MBI Flyer 
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com 

    McLean Hospital
    Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

    Beth Israel Deaconess Medical Center

    GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

    Sort by Study Type

    ➡ A Drug or Intervention Trial

    Prevention of Alzheimer’s Disease in Normal Adults

    • AHEAD (A3/A45) A preventative clinical trial aimed recruiting cognitively normal individuals with a positive amyloid status to assess the effectiveness of an investigational medication BAN2401 on individuals with both intermediate and elevated levels of amyloid.
      Contact: 617-278-0600
      Additional information: : https://www.aheadstudy.org
      Location:  60 Fenwood Road, Boston, MA

    Patients with Mild Cognitive Impairment

     BCG vaccine – BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad

    Location: 149 13th Street, Charlestown, MA   

    Trap-AD Study-Neuroimaging Research Study of Light Therapy in Mild Cognitive Impairment: The aim of this study is to better understand the effects of transcranial photobiomodulation (tPBM) on blood flow in the brain of individuals diagnosed with mild cognitive impairment, ages 65-85

     Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body

    Patients with Alzheimer’s Disease Dementia

    • Cyclerion – an investigational medication that penetrates the central nervous system and increases the activity of a molecule pathway that affects neuronal function, controls neuronal inflammation, and vascular function.
      Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
      Additional Information: https://rally.massgeneralbrigham.org/study/cyclerion
    • Location: 149 13th Street, Charlestown, MA

    BCG vaccine -BCG vaccine is thought to have “off target” effects in the immune system, specifically on T regulatory cells which maintain homesostasis of the immune response. This vaccine has been given to billions of people worldwide, as Japan BCG is used by UNICEF and WHO as the standard tuberculosis vaccination.

    Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-643-4802
    Additional Information: https://rally.massgeneralbrigham.org/study/bcg_in_ad

    Location: 149 13th Street, Charlestown, MA   

    • Athira – a phase II study of ATH -1017 , an investigational medication, given by subcutaneous injection. This study is being conducted to determine if ATH 1017 will promote the creation and protection of brain cells in individuals with Alzheimer’s disease
      Contact: Kate Cropp, KCROPP1@mgh.harvard.edu   617-723-2351
      Additional Information: https://rally.partners.org/study/ath_1017

      Location: 149 13th Street, Charlestown, MA

    • JNJ Autonomy Trial – A study for adults 55-80 years old with Alzheimer’s Disease to receive infusions of an experimental medication, JNJ-63733657, or a placebo (inactive) infusion. This study is being conducted to help determine the safety and efficacy of this experimental medication.
      Contact: Kate Cropp KCROPP1@mgh.harvard.edu 617-723-2351
      Additional Information:
      https://rally.partners.org/study/johnsonandjohnson

    • Novartis – A study of Canakinumab (ACZ885), an anti-inflammatory research drug, given by subcutaneous injection. This study is being conducted to determine if anti-inflammatory treatment has an effect on biomarkers in your body
      Contact: Kate Cropp, KCROPP1@mgh.harvard.edu 617-723-2351
      Additional Information:  https://rally.partners.org/study/novartis
      Location: 149 13th Street, Charlestown, MA

     

    NMN – Men and women aged 55-85 who are diagnosed with mild Alzheimer’s Disease are invited to join our study which is investigating if an oral dietary supplement can be beneficial for Alzheimer’s patients.Contact: Bella Levesque, ilevesque@bwh.harvard.eduAdditional Information:https://rally.massgeneralbrigham.org/study/adsupplement Location: 60 Fenwood Road Boston, MA 02115

    Patients with Frontotemporal Dementia or Primary Progressive Aphasia

    • Transcranial Magnetic Stimulation Study -This study evaluates use of repetitive transcranial magnetic stimulation to target areas of memory and language in patients with amnestic mild cognitive impairment and the logogenic or non-fluent variant of primary progressive aphasia.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    GIFTED This study explores the safety, tolerability, and effectiveness of 6 weeks of daily transcranial alternating current stimulation (tACS) in people with behavioral variant frontotemporal dementia (bvFTD). Cognitive testing, MRI scans, PET scans, and blood draws are used.                      

    Contact: Megan Hoffman mahoffma@bidmc.harvard.edu

    Affiliate Research Studies Contact:

    Northeastern University Music-Based Intervention Research Study
    MBI Flyer 
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com

    McLean Hospital
    Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

    Beth Israel Deaconess Medical Center

    GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

     

     

    ➡ An Observational Study (no drug or intervention):

    If you are Cognitively Normal (no memory loss or dementia):

    • APT Web study: Participants who are 50 years of age or older can take on-line 30-minute memory assessments every three months while researchers track their progress and contact them about new research studies available.
      www.aptwebstudy.org 
    • Instrumental Activities of Daily Living (IADL) A study that requires you to complete assessments that can may help clinicians make an early diagnosis of AD and monitor any change in daily functioning.                                                                                                                    

      Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/study_iadl
      Location: 149 13th Street, Charlestown, MA 

    • Alzheimer’s Disease EEG Sleep Study   A study to look at disrupted sleep dynamics and altered sleep oscillations to better understand the relationship between sleep and aging and Alzheimer’s disease in cognitively normal, Mild Cognitive Impairment and Alzheimer’s disease. This study will evaluate resting state EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) and PET/ MRI imaging biomarkers to better understand markers for preclinical and prodromal AD.

      Contact: purdonlab@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/noninvasive_biomarkers
      Location: 149 13th Street, Charlestown, MA 

    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

      Contact: MemoryAndAging@mgh.harvard.edu.                                                                                                    

    • Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.

      Contact: Danielle Ross,  dross6@mgh.harvard.edu or Raina Levin, rlevin4@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/sonnet                          Location:149 13th Street, Charlestown, MA

       

        

    Cognitively Normal and a Spanish Speaker

    • Boston Latino Aging Study (BLAST) A study to assess Spanish speaking participants cognitive function and recruit potential participants for other studies.
    • Contact: Jairo Martinez | jmartinez24@mgh.harvard.edu
    • Additional Information: BLAST Flyer Spanish
    • Location: 149 13th Street, Charlestown, MA 
    • Latino Harvard Aging Brain Study (HABS) A study that uses multiple imaging techniques to study the structure and function of the brain and to detect the presence of amyloid.
    • Contact: Jairo Martinez jmartinez24@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/_latino_habs
      Location: 149 13th Street, Charlestown, MA
    • Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.
      Contact: MemoryAndAging@mgh.harvard.edu

    Older Adults Concerned About Their Memory (Subjective Cognitive Decline)

    • Subjective Cognitive Decline (SCD) A study that asks participants with subjective complaints complete at home assessments and have neuroimaging testing.                    


      Contact:
      Zoe Katz, zskatz@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/study_scd
      Location:
      149 13th Street, Charlestown, MA.    

       

    • Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to tau and amyloid build-up in the brain.


      Contact: 
      Danielle Ross,  dross6@mgh.harvard.edu or
      Raina Levin, rlevin4@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/sonnet                          Location:149 13th Street, Charlestown, MA

    Patients with Mild Cognitive Impairment

    • Instrumental Activities of Daily Living (IADL)A study that requires you to complete assessments that can may help clinicians make an early diagnosis of Alzheimer’s disease and monitor any change in daily functioning.

      Contact: Onyinye Udeogu, oudeogu@mgh.harvard.edu                                       
      Additional information: https://rally.partners.org/study/study_iadl                 Location: 149 13th Street, Charlestown, MA 

    • Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in AD by analyzing EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain) data.

      Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
      Location: 149 13th Street, Charlestown, MA 

    • Alzheimer’s Disease EEG Sleep Study  A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).

      Contact: purdonlab@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/risk_of_alzheimers
      Location: 149 13th Street, Charlestown, MA     

    Patients with Alzheimer’s Disease Dementia

    • Memory Awareness – A study investigating how assessing one’s own memory performance changes in normal aging and in people diagnosed with Mild Cognitive Impairment or Alzheimer’s Disease.
      Contact: Sharon Wang, swang72@mgh.harvard.edu                                                Additional info:                  https://rally.partners.org/study/the_memoryawareness_study.                            Location: 149 13th Street, Charlestown, MA 
    • Sleep on Neural Networks in Brain Aging (SONNET) A study to help us understand how individual variations in sleep are related to proteins (tau and amyloid) build-up in the brain.
      Contact: Nick Stevenson, nestevenson@mgh.harvard.edu
      Additional information https://rally.partners.org/study/sonnet
      Location: 149 13th Street, Charlestown, MA 
    • Multimodal investigation of hyperexcitability in Alzheimer’s disease – A study looking at hyperexcitability in individuals with dementia from probable Alzheimer’s Disease or Mild Cognitive Impairment. Participants will have a 12-hour overnight EEG (electroencephalogram a test used to evaluate the electrical activity in the brain) at their home.
      Contact: Molly Lawrence (617) 726-3086  mlawrence9@bwh.harvard.edu
      Additional information: Multimodal flyer
      Location: 149 13th Street, Charlestown, MA 
    • Lifespan Biobank -This study is designed to create a biobank that consists of blood, cerebral spinal fluid (CSF), and other bodily fluid to gain a better understanding of various neurodegenerative diseases.
      Contact: KCROPP1@mgh.harvard.edu   (617) 643-4802                                           Additional information: https://rally.partners.org/study/lifespan_biobank.   Location: 149 13th Street, Charlestown, MA 
    • Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA
    • Longitudinal Early Onset Disease Study (LEADS) A study to compare biomarker data of cognitively impaired (Early Onset Alzheimer’s Disease and non-Early Onset Alzheimer’ Disease) and Clinically Normal to Longitudinal Alzheimer’s Disease participants.
      Contact: Ana Eustace, AEUSTACE@mgh.harvard.edu
      Additional information: AA_LEADS-Brochure_
      Location: 149 13th Street, Charlestown, MA
    • Alzheimer’s Disease EEG Sleep Study   A study to look at pre -clinical diagnosis and longitudinal tracking of Alzheimer’s Disease using Sleep and Resting State EEG (electroencephalogram-a test used to evaluate the electrical activity in the brain).
      Contact: purdonlab@mgh.harvard.edu
      Additional information: https://rally.partners.org/study/noninvasive_biomarkers
      Location: 149 13th Street, Charlestown, MA 

     Resilient Together Study- A study seeking to understand the experiences, needs, and preferences of individuals with a form of young onset dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.

     Dementia, Care Planning and Surgery -This is a study to help understand the effectiveness of advance care planning for participants with dementia and either considering or considered surgery.

    Memory & Aging Cohort Study (MAC): Participants age 45+ will complete memory tests, a blood draw and questionnaires in one study visit. This study is looking at the relationship between the substances in your blood and your memory and thinking abilities. You will be compensated $50 for this visit.

    • Ornish – A research study designed to see if lifestyle changes may slow down, lessen, or potentially reverse the progression of Alzheimer’s disease. Participants in this study will make changes to their diet, and participate in daily exercise, stress management, and group support.
    • Contact: Joe Wood, JWOOD20@mgh.harvard.edu  617-643-4802Additional Information https://rally.partners.org/study/lifestyleintervention  Location: 149 13th Street, Charlestown, MA    

     

    Patients with Frontotemporal Dementia, Primary Progressive Aphasia, Posterior Cortical Atrophy, Progressive Supranuclear Palsy or Corticobasal Syndrome

    • ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)– A longitudinal study of participants with diagnosis of FTD, symptoms of FTD or, who have a strong family history of FTD.
      Contact:
      Erin Krahn, ekrahn@mgh.harvard.edu

     

    • Tau PET Imaging Study – A Longitudinal study of participants with primary progressive aphasia, posterior cortical atrophy, or Alzheimer’s disease to evaluate using Tau imaging.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

     

    • 4-Repeat Tauopathy Neuroimaging Initiative, Cycle 2 Study (4RTNI-2) This study monitors the process of multiple brain disorders using imaging, bodily fluids, and cognitive testing in participants with progressive supranuclear palsy or corticobasal syndrome.
      Contact: Katie Cunningham, KCUNNINGHAM15@mgh.harvard.edu
      Location: 149 13th Street, Charlestown, MA

    Patients with Lewy Body Dementia or Parkinson’s Disease with Dementia

      • Investigation of Epigenetic Mechanisms in Parkinson’s Disease Patients Quantified by Non-Invasive PET Imaging – This study is looking at master regulators of gene expression in dementia with Lewy bodies and Parkinson disease. Contact: Molly Quan mquan4@mgh.harvard.edu

        Location: 149 13th Street, Charlestown, MA

      • Lewy AD Study, Imaging AD Pathology in Parkinson Disease and Dementia with Lewy Body – Is an imaging Alzheimer’s disease pathology study in dementia with Lewy bodies and Parkinson disease study.
        Contact: Molly Quan mquan4@mgh.harvard.edu

        Location: 149 13th Street, Charlestown, MA

    Patients with Vascular Disease and Cerebral Amyloid Angiopathy

    • Vascular Pathology in Early and Asymptomatic Cerebral AngiopathyThis study aims to identify signature markers through MRIs and memory/attention testing to learn more about the progression of both Cerebral Amyloid Angiopathy and memory loss.
      Contact: Vanessa Gonzalez vagonzalez@mgh.harvard.edu

      Additional information: https://rally.partners.org/study/caamemorystudy
      Location: Mass General Hospital

    A Caregiver

    • Caregiver Burden Study -A study to better understand how to develop behavioral intervention techniques to reduce caregiver burden for individuals caring for someone with Frontal Temporal Lobe Dementia or ALS.
      Contact Erin Krahn: ekrahn@mgh.harvard.edu

      Location: 149 13th Street, Charlestown, MA 

    • Resilient Together A study that seeks to understand the experiences, needs, and preferences of individuals with a form of Young Onset Dementia (YOD) and their spousal caregivers through video interviews to develop a toolkit to facilitate the usage of skills in navigating challenges after diagnosis.
      Contact: Paula Popok: 617-724-0051 ppopok@mgh.harvard.edu
    • Additional information https://rally.partners.org/study/resilienttogether
      Location: 149 13th Street, Charlestown, MA

    Affiliated research partner studies contact:

     McLean Hospital
    Contact: Isabella Santangelo  isantangelo@mclean.harvard.edu

    Northeastern University Music-Based Intervention Research Study 
    MBI Flyer
    https://web.northeastern.edu/mindlab/
    Contact: mindlabwes@gmail.com

    Beth Israel Deaconess Medical Center

    GammaR01- A 3-4 month study to explore effects and safety of non-invasive brain stimulation in participants with a diagnosis of MCI to moderate AD. Participants will undergo MRI, PET, EEG, non-invasive brain stimulation, and neurocognitive tests.

    Contact: Nainika Grover  617-667-0362  ngrover@bidmc.harvard.edu

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