E. Tessa Hedley-Whyte
Professor of Pathology, Harvard Medical School
Massachusetts General Hospital, Harvard Medical School
(617) 726-5154
Neuropathology; autopsy pathology; frozen section pathology
I have spent many years studying various aspects of neurodegenerative diseases in collaboration with other members of the Massachusetts Alzheimer’s Disease Research Center (ADRC) and I continue to mentor trainees and colleagues in the diagnosis and classification of these diseases. In this role, I am responsible for the diagnosis of approximately half of the postmortem cases from the ADRC.
More Information: Hedley-Whyte Profile
Newell KL, Hyman BT, Growdon JH, Hedley-Whyte ET. Application of the National Institute of Aging (NIA)-Reagan Institute Criteria for the Neuropathological Diagnosis of Alzheimer’s Disease. J Neuropathol Exper Neurol 1999; 58: 1147-1155.
Silver MH, Newell KKL, Brady C, Hedley-Whtye ET, Perls TT. Distinguishgin Between Neurodegenerative Disease and Disease-Free Aging: Correlating Neuropsychological Evaluations and Neuropathological Studies in Centenarians. Psychosom Med 2002; 64: 493-501.
Ingelsson M, Fukumoto H, Newell K, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC. Early Abeta Accumulation and Progressive Synaptic Loss, Gliosis and Neurofibrillary Tangle Formation in AD Brain. Neurology 2004; 62: 925-931.
Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch M, Growdon JH, McLean P, Hyman BT. Clinical and Biochemical Correlates of Insoluble Alpha Synuclein in Dementia with Lewy Bodies. Acta Neuropathol 2006; 111: 101-108.
Hedley-Whyte ET. On Being a Pathologist: How Does One Plan a Career or Does One? Hum Pathol 2008; 39: 1269-1274.
Freeman SH, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Locascio JJ, Lipsitz LA, Hyman BT. Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy in Elderly Subjects without Alzheimer’s Disease. J Neuropathol Exp Neurol 2007; 67: 1205-121. [PMCID: 2734185].
McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee H-Y, Kubilus CA, Stern RA. Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy After Repetitive Head Injury. J Neuropathol Exp Neurol 2009; 68: 709-735. [PMCID: 2945234].
McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perls D, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee H-Y, Kubilus CA, Danshevar D, Wulff M, Budson AE. TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy. J Neuropath Exp Neurol 2010; 69: 918-929. [PMCID: 2951281].
Lain AH, Lieberman Ap, Pfannl R, Hedley-Whyte ET. Nodular Bilateral Amygdala Degeneration in Demented Individuals. Acta Neuropathol 2010; 120: 683-688. [PMCID: 3057016].
Margolin DH, Kousi M, Chan Y-M, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O’Rourke J, Kirby A, Lage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB. Ataxia, Dementia and Hypogonadotropism Caused by Disordered Ubiquitination. N Engl J Med 2013; 368: 1992-2003. [PMCID: 3738065].
More publications may be found at www.ncbi.nlm.nih.gov/
